alexa Olive Leaves and Mill Waste Exert Anti-Tumoral Properties in Hepatoma Cell Line | OMICS International | Abstract
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Research Article

Olive Leaves and Mill Waste Exert Anti-Tumoral Properties in Hepatoma Cell Line

Isidora Ranchal1, María D Luque de Castro2 and Jordi Muntané1-4*

1 Unit for the Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, Sevilla, Spain

2 Department of Analytical Chemistry, IMIBIC (Instituto Maimónides para la Investigación Biomédica de Córdoba), University of Córdoba, Córdoba, Spain

3 Department of General Surgery, Hospital Universitario Virgen del Rocío/IBiS/CSIC/Universidad de Sevilla, Seville, Spain

4 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

*Corresponding Author:
Jordi Muntané
Instituto de Biomedicina de Sevilla
Hospital Universitario Virgen del Rocío
Av. Manuel Siurot s/n, 410013 Sevilla, Spain
Tel: +34955923122
Fax: +34955923101
E-mail: [email protected]

Received date: March 11, 2014; Accepted date: April 26, 2014; Published date: May 07, 2014

Citation: Ranchal I, de Castro ML, Muntané J (2014) Olive Leaves and Mill Waste Exert Anti-Tumoral Properties in Hepatoma Cell Line. J Carcinog Mutagen 5:170. doi: 10.4172/2157-2518.1000170

Copyright: © 2014 Ranchal I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Different phenolic compounds such as oleuropein and hydroxytyrosol have demonstrated antitumoral activity in cancer cell lines. Olive derivatives have demonstrated beneficial properties in cardiovascular diseases. The study was addressed to show the potential beneficial properties of olive leaves and olive oil mill waste extracts in hepatoma cell lines. Aflatoxin B1 (AFB1) was administered to hepatoma cell line (HepG2). Different parameters related to cell death, cell proliferation and DNA damage were determined. The expression of p53 and c-Src (activated and inhibitory phosphorylated state) was assessed by Western blot analysis in HepG2. The olive leaves and olive oil mill waste extracts contained oleuropein and hydroxytyrosol, respectively. AFB1 induced cell proliferation and death, associated to a rise on p53 and c-Src expression in HepG2 cells. Oleuropein and hydroxytyrosol reduced cell necrosis and DNA damage in HepG2 cells. However, the administration of olive leaves and olive oil mill waste extracts increased cell necrosis and DNA damage. These effects of natural extracts were associated with a reduction of activated c-Src expression and cell proliferation in AFB1-treated HepG2 cells. These results support that olive leaves extract and olive oil mill waste extracts, but not oleuropein and hydroxytyrosol, may exert antitumoral effect against a hepatoma cancer cell line.


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