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Omalizumab: Anti-IgE Therapy in Severe Allergic Conditions | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
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Research Article

Omalizumab: Anti-IgE Therapy in Severe Allergic Conditions

Arzu Didem Yalcin1* and Atil Bisgin2

1Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey

2Department of Medical Genetics, Antalya, Turkey

*Corresponding Author:
Arzu Didem Yalcin
Department of Internal Medicine
Allergy and Clinical Immunology Unit
Antalya Education and Research Hospital
Antalya, Turkey
E-mail: [email protected]

Received date: September 04, 2012; Accepted date: September 17, 2012; Published date: September 21, 2012

Citation: Yalcin AD, Bisgin A (2012) Omalizumab: Anti-IgE Therapy in Severe Allergic Conditions. J Aller Ther 3:120. doi: 10.4172/2155-6121.1000120

Copyright: © 2012 Yalcin AD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: The primary use of omalizumab (trade name Xolair) is for patients with severe, persistent and allergic asthma. Our aim was to evaluate the therapeutic efficacy of omalizumab as a treatment modality in patients with different allergic conditions.
Methods: There were eleven patients, whom followed-up with omalizumab therapy in the Immunology - Allergy Clinic, were evaluated by the clinical findings of nasal polyposis, anaphylaxis history, drug allergy, latex allergy, food allergy, autoimmune urticaria, allergic rhino-conjunctivitis, atopic dermatitis, angioedema and venom allergy.
Results: The patients, who had severe persistent asthma for periods ranging from 3 to 8 years, were enrolled in the study. Omalizumab was chosen as a potential new systemic therapy for the patients due to the clinical indication. Clinical symptoms of the all patients with severe persistent asthma were decreased. And in addition, asthma control test and pulmonary function tests were improved up. A severe anaphylactic reaction is prevented in a patient with 48 bee stings.
Conclusion: This clinical follow-up of omalizumab treated patients with severe persistent asthma and many different allergic conditions, suggests omalizumab is an effective therapy for asthma and different allergic conditions.


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