alexa On the Effect of Aromatherapy with Citrus Fragrance in the Therapy of Major Depressive Disorder
ISSN: 2161-0487

Journal of Psychology & Psychotherapy
Open Access

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Short Communication

On the Effect of Aromatherapy with Citrus Fragrance in the Therapy of Major Depressive Disorder

Maria Alice Ornellas Pereira* and Alfredo Pereira Jr.

Universidade Estadual Paulista Julio de Mesquita Filho, Brazil

Corresponding Author:
Maria Alice Ornellas Pereira
Universidade Estadual Paulista Julio de Mesquita Filho
Enfermagem, Travessa das Palmeiras
93, Botucatu-SP-18607-420, Brazil
Tel: 55-14-3882-2459
E-mail: [email protected]

Received date: December 29, 2014; Accepted date: February 17, 2015; Published date: February 24, 2015

Citation: Maria AOP, Alfredo PJr (2015) On the Effect of Aromatherapy with Citrus Fragrance in the Therapy of Major Depressive Disorder. J Psychol Psychother 5:169. doi:10.4172/2161-0487.1000169

Copyright: © 2015 Pereira MAO et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The effect of aromatherapy on the human central nervous system is a controversial issue in medical sciences. Here we present a hypothesis relating citrus fragrance aromatherapy with brain glucose homeostasis in Major Depressive Disorder. How to conciliate the correlation between depression and resistance to insulin with the fact that glucose transport to neurons is not made directly by insulin? We briefly discuss the mechanism of dynamical glucose balance in the brain, which includes lactate transport from astrocytes to neuronal mitochondria supporting ATP (and then cAMP) production. We hypothesize that odors like vanillin and citrus fragrances fool the brain’s glucose level sensors, reducing the subjective feeling of "low energy". This hypothesis can help to explain the surprisingly positive results found in the treatment of depression with aromatherapy.


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