alexa On the Futile Existence of DHA, None of EPA and the Pre
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

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Research Article

On the Futile Existence of DHA, None of EPA and the Predominant Role of the Triacylglycerols (TGs) in the Post Mortem Human Brain: An LCMS Study with Evolutionary Implications

Vincent van Ginneken1,2*, Aline van Meerveld1, Elwin Verheij2 and Jan van der Greef2,3

1Blue Green Technologies, Runderweg 6, 8219 PK Lelystad, The Netherlands

2Netherlands Organisation for Applied Scientific Research (TNO), Utrechtseweg, AJ Zeist, The Netherlands

3Sino-Dutch Center for Preventive and Personalized Medicine; Leiden University, RA Leiden, The Netherlands

*Corresponding Author:
Vincent van Ginneken
Blue Green Technologies, Runderweg 6, 8219 PK Lelystad
The Netherlands
Tel: 310638071180
E-mail: [email protected]

Received date: June 03, 2017; Accepted date: June 17, 2017; Published date: June 23, 2017

Citation: Ginneken VV, Meerveld AV, Verheij E, Greef JVD (2017) On the Futile Existence of DHA, None of EPA and the Predominant Role of the Triacylglycerols (TGs) in the Post Mortem Human Brain: An LCMS Study with Evolutionary Implications. J Bioanal Biomed 9:152-158. doi: 10.4172/1948-593X.1000170

Copyright: © 2017 Ginneken VV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



What is known about the brain is a scanty amount of information despite its importance in human evolution. Here we perform based on a holistic Systems Biology lipidomics approach an attempt describing the brain biochemical lipid composition based on the homogenate of a part (gyrus) of the neocortex of post mortem material of the “Dutch Brain Bank” with LCMS techniques. From evolutionary perception the occurrence of the “fish oils” in blood and/ or brain is interesting and their ability to pass the Blood-Brain Barrier (BBB). Both omega-3 “fish oil” Fatty Acids (FA) Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA). EPA and DHA are found in rather high concentrations respectively 0.277% and 0.258% respectively in blood plasma but not in the brain. EPA is not found in grey or white neocortex matter so probably it cannot pass the BBB while this is the case for DHA giving values of respectively ≈0.00015% while Triacylglycerols (TGs) are the major constituent of the human brain with a mean value of the neocortex of ≈72%. We finally conclude the TGs have played a major role in the process of human brain growth and encephalization during course of evolution.


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