alexa Once Daily Dose of Nevirapine (400 mg) Versus Twice-Dai
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

Once Daily Dose of Nevirapine (400 mg) Versus Twice-Daily Dose (200 mg) of Nevirapine-Based Highly Active Antiretroviral Therapy Regimens in Antiretroviral Naïve Patients with HIV and Tuberculosis Infection in India

Sanjeev Sinha1*, Suvrit Jain1, Kartik Gupta1, Nawaid Hussain1, Sanjay Ranjan1, Velpandian T2, Kamal Kishore3and Pandey RM4

1Departments of Medicine, All India Institute of Medical Sciences, New Delhi, India

2Ocular Pharmacology and Pharmacy, RPC, All India Institute of Medical Sciences, New Delhi, India

3Pharmacology, All India Institute of Medical Sciences, New Delhi, India

4Biostatistics, All India Institute of Medical Sciences, New Delhi, India

*Corresponding Author:
Dr. Sanjeev Sinha
Professor, Department of Medicine
All India Institute of Medical Sciences
Ansari Nagar, New Delhi 110029, India
Tel: 91-9810164416
Fax: 011-26588866
E-mail: [email protected]

Received date: March 26, 2017; Accepted date: April 10, 2017; Published date: April 17, 2017

Citation: Sinha S, Jain S, Gupta K, Hussain N, Ranjan S, et al. (2017) Once a Daily Dose of Nevirapine (400 mg) Versus Twice-Daily Dose (200 mg) of Nevirapine- Based Highly Active Antiretroviral Therapy Regimens in Antiretroviral Naïve Patients with HIV and Tuberculosis Infection in India. J AIDS Clin Res 8:689. doi:10.4172/2155-6113.1000689

Copyright: © 2017 Sinha S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Nevirapine-based antiretroviral therapy against human immunodeficiency virus (HIV) among Tuberculosis (TB) co-infected individual is complicated as administration of rifampicin along with Nevirapine reduces the plasma concentration of Nevirapine. The objective of the present study is to compare efficacy and safety of Nevirapine 400 mg once daily (OD) based antiretroviral therapy (ART) with efavirenz based ART and twice daily dose (200 mg) of Nevirapine-based ART regimens in HIV-TB co-infected individuals. ART-naïve HIV-TB patients were randomly assigned to receive either Nevirapine 400 mg OD with zidovudine and lamivudine (Group 1; n=30), Nevirapine 200 mg BD (Group 2; n=30), efavirenz 600 mg (Group 3, n=31); Nevirapine 400 mg OD with tenofovir (Group 4; n=30) and Nevirapine 400 mg OD without concomitant antitubercular therapy (ATT) (Group 5; n=30). The end points were virological (viral load), immunological (CD4 count) and clinical responses and progression of HIV disease marked by the failure of ART. Our results suggest that Nevirapine 400 mg OD based therapy is as effective as efavirenz-based ART in terms of clinical, immunological and virological response. Our data suggests that Nevirapine 400 mg OD group had favorable treatment outcome as compared to Nevirapine 200 mg 1 BD group.

We conclude that Nevirapine 400 mg OD based ART combined with tenofovir and lamivudine could be an effective alternative to improve compliance in the resource-limited settings in patients with HIV-TB co-infection. Further large multicentric study with bigger sample size will be required to confirm these findings.

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