alexa OncoLncs: Long Non-Coding RNAs with Oncogenic Functions
ISSN: 2168-9547

Molecular Biology: Open Access
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Review Article

OncoLncs: Long Non-Coding RNAs with Oncogenic Functions

Esra Bozgeyik1, Emine Bayraktar1,2, Arturo Chavez-Reyes3 and Cristian Rodriguez-Aguayo2*

1Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep 27310, Turkey

2Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA

3Centro de Investigación y Estudios Avanzados del IPN, Unidad Monterrey. Apodaca, NL. CP. 66600, Mexico

*Corresponding Author:
Cristian Rodriguez-Aguayo
Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNA
The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
E-mail: [email protected]

Received date: April 23, 2016; Accepted date: May 04, 2016; Published date: May 11, 2016

Citation: Bozgeyik E, Bayraktar E, Chavez-Reyes A, Rodriguez-Aguayo C (2016) OncoLncs: Long Non-Coding RNAs with Oncogenic Functions. Mol Biol 5:162. doi:10.4172/2168-9547.1000162

Copyright: © 2016 Bozgeyik E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A decade before the discovery of non-coding transcripts, approximately 98% of the human genome was known as “transcriptional noise” or “junk DNA”. However, with the recent findings, non-coding transcripts are continuously turning into functional non-coding RNAs (ncRNA). NcRNAs comprise multiple classes of RNA transcripts that are not transcribed into proteins but have shown to regulate the transcription, stability, or translation of protein-coding genes in the mammalian genome. Nowadays the most studied ncRNAs are called miRNAs. They have been involved in the biogenesis and development of cancer. More recently, long non-coding RNAs (lncRNAs) were discovered and they have been shown not only to play a role in transcriptional and translational regulation, but also be involved in several diseases including cancer. LncRNAs are RNA transcripts longer than 200 nucleotides that do not encode proteins. The accumulating body of evidence suggests that lncRNAs play important roles in a variety of biological processes. They have been reported to be altered in many pathological states including cancer. LncRNAs with oncogenic functions (we may call; OncoLncs) were reported to be overexpressed in cancer cells and involved in the hallmarks of cancer including sustained proliferation, invasion, and metastasis. The field of regulatory RNAs is continuously growing especially the lncRNAs. Thus, in this comprehensive review, we discussed the advances on OncoLncs field in the malignant transformation of cancer and the therapeutics opportunities.

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