alexa One Hundred Years of Heparin
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Opinion Article

One Hundred Years of Heparin

Gargantilla P1,2*, Arroyo N1 and Pintor E2
1Department of Internal Medicine, Hospital de El Escorial, Madrid, Spain
2European University of Madrid, Spain
Corresponding Author : Pedro Gargantilla
Department of Internal Medicine
Hospital de El Escorial
Madrid, Ctra. Guadarrama-Escorial Km 6
255, 28200 El Escorial
Madrid, Spain
Tel: +34 918 97 30 00
E-mail: [email protected]
Received: December 23, 2015, Accepted: December 29, 2015 Published: December 31, 2015
Citation: Gargantilla P, Arroyo N, Pintor E (2015) One Hundred Years of Heparin. J Hematol Thrombo Dis 3:230. doi: 10.4172/2329-8790.1000230
Copyright: © 2015 Gargantilla P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

This year is the 100th anniversary of the discovery of heparin, the main anticoagulant drugs for more than 70 years [1], and we would like to remind its discovery. Heparin is a highly-sulfated glycosaminoglycan. It was first discovered by J McLean and WH Howell. McLean was a second-year medical student, at Johns Hopkins University, who was assisting Howell in the investigation of procoagulant preparations. Howell sugggestd to him that he study the nature of the thromboplastic substance to identify the active principle of this extract. In 1916 the young student isolated a fat-soluble anticoagulant in canine liver tissue [2]. It was discovered serendipitously in the course of a problem.

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