alexa One Pot Synthesis, Antimicrobial and<em> In Silico</em> Molecular Docking Study of 1,3-Benzoxazole-5-Sulfonamide Derivatives | OMICS International| Abstract

ISSN: 2161-0401

Organic Chemistry: Current Research

  • Research Article   
  • Organic Chem Curr Res,
  • DOI: 10.4172/2161-0401.1000163

One Pot Synthesis, Antimicrobial and In Silico Molecular Docking Study of 1,3-Benzoxazole-5-Sulfonamide Derivatives

Vinoda BM1, Bodke YD1*, Vinuth M1, Aruna Sindhe M1, Venkatesh T1 and Sandeep Telkar2
1Department of PG Studies and Research in Industrial Chemistry, Kuvempu University, Karnataka-577 451, India
2Department of PG Studies and Research in Biotechnology, Kuvempu University, Karnataka-577 451, India
*Corresponding Author : Bodke YD, Department of PG Studies and Research in Industrial Chemistry, Kuvempu University, Karnataka-577 451, India, Tel: +918282256228, Email: [email protected]

Received Date: Apr 01, 2016 / Accepted Date: Apr 11, 2016 / Published Date: Apr 18, 2016

Abstract

A series of 1,3-benzoxazole-5-sulfonamide derivatives have been synthesized via acetophenones, aldehydes and 2-sulfanyl-1,3-benzoxazole-5-sulfonamide using Fe(III)-montmorillonite (Fe(III)-mont) as catalyst. Catalyst is good Lewis acid and support to increase the yield of the final compounds. The structures of newly synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR and Mass spectroscopic methods. The antimicrobial potential of title compounds was tested against several bacterial and fungal strains. Some compounds exhibited comparable or better antimicrobial activity in comparison to the reference drugs Ciprofloxacin and Fluconozole. The selected compounds were also subjected for in silico molecular docking study.

Keywords: Fe(III)-Montmorillonite; Multi component reactions; Antimicrobial activity; In silico molecular docking study

Citation: Vinoda BM, Bodke YD, Vinuth M, Sindhe MA, Venkatesh T, et al. (2016) One Pot Synthesis, Antimicrobial and In Silico Molecular Docking Study of 1,3-Benzoxazole-5-Sulfonamide Derivatives. Organic Chem Curr Res 5: 163. Doi: 10.4172/2161-0401.1000163

Copyright: © 2016 Vinoda BM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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