alexa Ophthalmoparesis Mimicking Myasthenia Gravis as Acute Manifestation of Hashimoto’s Encephalopathy
ISSN: 2376-0389

Journal of Multiple Sclerosis
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Case Report

Ophthalmoparesis Mimicking Myasthenia Gravis as Acute Manifestation of Hashimoto’s Encephalopathy

Mariotto S1, Bonetti B1*, Donato F2, Micheletti N2, Zanoni T2, Moretto G2 and Squintani G2

1Section of Neurology, Department of Neurological and Movement Sciences, University of Verona, Verona, Italy

2Section of Neurology, Department of Neuroscience, Azienda Ospedaliera Universitaria Integrata, Verona, Italy

*Corresponding Author:
Bruno Bonetti
University of Verona Verona, Italy
Tel: +390458124694
E-mail: [email protected]

Received date: December 31, 2014, Accepted date: February 20, 2015, Publication date: February 23, 2015

Citation: Mariotto S, Bonetti B, Donato F, Micheletti N, Zanoni T, et al (2015) Ophthalmoparesis Mimicking Myasthenia Gravis as Acute Manifestation of Hashimoto’s Encephalopathy. J Mult Scler 2:134. doi:10.4172/2376-0389.1000134

Copyright: © 2015 Mariotto et al,. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Hashimoto’s encephalopathy is a rare steroid-responsive disorder in which neuropsychological and neurological symptoms are associated with Hashimoto’s thyroiditis. Recently, it has gained attention in the differential diagnosis of encephalopathy of unknown origin, although its pathogenesis is poorly understood. The diagnosis of Hashimoto’s encephalopathy rests upon the association of autoimmune thyroiditis and neurological symptoms after excluding more common diseases, but is a serious challenge in atypical cases. We here present a patient with isolated ocular disorder as presenting and unic feature of Hashimoto’s encephalopathy that resolved with steroids therapy. Brain MRI showed non-specific white matter abnormalities; EEG and an extensive neurophysiological investigation were normal. The diagnosis in this euthyroid patient was supported by the presence of serum anti-thyroid antibodies and the identification in the CSF of anti-dimethylargininase-I and aldehyde reductase-I autoantibodies. The description of atypical cases of this rare but certainly underestimated condition is clinically important and adds relevant information for the clinical practice.


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