alexa Opioid Antagonists Enhance Diabetic Wound Closure: A New Therapy
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Opioid Antagonists Enhance Diabetic Wound Closure: A New Therapy

Patricia J McLaughlin* and Ian SZagon

Pennsylvania State University College of Medicine, Hershey PA, USA

*Corresponding Author:
Patricia J McLaughlin
Pennsylvania State University College of Medicine
Hershey PA 17033, USA
Tel: 717-531-6414
E-mail: [email protected]

Received Date: November 07, 2014; Accepted Date: November 20, 2014; Published Date: November 28, 2014

Citation: McLaughlin and Ian SZagon (2014) Opioid Antagonists Enhance Diabetic Wound Closure: A New Therapy. Transl Med (Sunnyvale) 4:142. doi:10.4172/2161-1025.1000142

Copyright: © 2014 McLaughlin, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A major complication of type 1 or type 2 diabetes involves proper healing of cutaneous wounds. Diabetic wounds heal slowly and treatments do not mediate the underlying pathophysiology. Enkephalins are reported to be elevated in diabetes and one enkephalin, opioid growth factor (OGF), serves as an inhibitory growth factor that delays cell replication. OGF interacts with its receptor, OGFr, to mediate cellular homeostasis, including wound repair. Blockade of the inhibitory function of OGF using the antagonist naltrexone (NTX) accelerates cell proliferation in a receptormediated, non-toxic manner. Topical application of NTX to full-thickness cutaneous wounds in type 1 diabetic rats and type 2 diabetic mice accelerated three phases of wound closure that are normally [defective, retarded] in diabetes including initial re-epithelialization, new blood vessel formation, and establishment of granulation tissue and integrity of the skin. These data support observations that a novel biological pathway is impaired under diabetic conditions and can be corrected by topical NTX to accelerate diabetic wound healing

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords