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ISSN: 2161-1025

Translational Medicine
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Review Article

Opioid Antagonists Enhance Diabetic Wound Closure: A New Therapy

Patricia J McLaughlin* and Ian SZagon

Pennsylvania State University College of Medicine, Hershey PA, USA

*Corresponding Author:
Patricia J McLaughlin
Pennsylvania State University College of Medicine
Hershey PA 17033, USA
Tel: 717-531-6414
E-mail: [email protected]

Received Date: November 07, 2014; Accepted Date: November 20, 2014; Published Date: November 28, 2014

Citation: McLaughlin and Ian SZagon (2014) Opioid Antagonists Enhance Diabetic Wound Closure: A New Therapy. Transl Med (Sunnyvale) 4:142. doi:10.4172/2161-1025.1000142

Copyright: © 2014 McLaughlin, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A major complication of type 1 or type 2 diabetes involves proper healing of cutaneous wounds. Diabetic wounds heal slowly and treatments do not mediate the underlying pathophysiology. Enkephalins are reported to be elevated in diabetes and one enkephalin, opioid growth factor (OGF), serves as an inhibitory growth factor that delays cell replication. OGF interacts with its receptor, OGFr, to mediate cellular homeostasis, including wound repair. Blockade of the inhibitory function of OGF using the antagonist naltrexone (NTX) accelerates cell proliferation in a receptormediated, non-toxic manner. Topical application of NTX to full-thickness cutaneous wounds in type 1 diabetic rats and type 2 diabetic mice accelerated three phases of wound closure that are normally [defective, retarded] in diabetes including initial re-epithelialization, new blood vessel formation, and establishment of granulation tissue and integrity of the skin. These data support observations that a novel biological pathway is impaired under diabetic conditions and can be corrected by topical NTX to accelerate diabetic wound healing

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