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ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Opioid-Induced Cardioprotection against Ischemia-Reperfusion Injury: The Challenge in Diabetes

Shaoqing Lei1,2,3, Wating Su1, Rui Xue1, Huimin Liu1, Liangqing Zhang2, Huilai Miao2, Youtan Liu2, Haobo Li3, Michael G Irwin3 and Zhengyuan Xia2,3*

1Department of Anaesthesiology, Renmin Hospital of Wuhan University, Wuhan, China

2Department of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China

3Department of Anaesthesiology, the University of Hong kong, Hongkong SAR, China

*Corresponding Author:
Dr. Zhengyuan Xia
Department of Anaesthesiology
The University of Hong Kong, Hong Kong
Tel: 852-3917-9794; 852-3917-9786
Email: [email protected]

Received date: October 01, 2015 Accepted date: October 13, 2015 Published date: October 16, 2015

Citation: Lei S, Su W, Xue R, Liu H, Zhang L, et al. (2015) Opioid-Induced Cardioprotection against Ischemia-Reperfusion Injury: The Challenge in Diabetes. J Diabetes Metab 6:616. doi:10.4172/2155-6156.1000616

Copyright: © 2015 Lei S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Ischemic heart disease is the leading cause of

morbidity

and mortality in diabetes. Patients with diabetes are particularly at risk of perioperative myocardial infarction, and are less resistant to myocardial ischemia-reperfusion injury (IRI), but the underlying mechanisms are very unclear. Opioid conditioning has been well demonstrated to be protective against myocardial IRI like ischemic conditioning, but this effect is compromised in diabetic condition, and little is known about the role of opioid-induced cardioprotection during diabetes. This brief review is to provide a summary of our present understanding of the effects of diabetes on opioids induced

protection

against myocardial IRI and the challenges of limiting IRI by opioids in the

diabetic heart

.

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