Reach Us +44-1202-068036
Optimal Sampling Times for Therapeutic Drug Monitoring | OMICS International | Abstract
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Optimal Sampling Times for Therapeutic Drug Monitoring

Aize Franciscus van der Meerm1* and Cees Neef2
1Maastricht University Medical Centre, Maastricht, the Netherlands
2CAPHRI, School for Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands
*Corresponding Author : Aize Franciscus van der Meerm
Maastricht University Medical Centre
Maastricht, the Netherlands
E-mail: [email protected]
Received October 03, 2012; Accepted October 29, 2012; Published October 31, 2012
Citation: van der Meerm AF, Neef C (2012) Optimal Sampling Times for Therapeutic Drug Monitoring. Adv Pharmacoepidem Drug Safety S1:004. doi:10.4172/2167-1052.S1-004
Copyright: © 2012 van der Meerm AF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Therapeutic drug monitoring has evolved from simple concentration measurements to estimating the level of exposure of to the drug and making dosage recommendations. Optimal sampling strategies are commonly used in therapeutic drug monitoring to optimize drug therapy. Optimal sampling strategies aim to determine the sampling times which will produce the most accurate estimation of pharmacokinetic parameters or exposure indices. The methodology used to create optimal sampling strategies is diverse and heterogeneous. Multiple regression analysis has been surpassed by Maximum A Posteriori Bayesian (MAPB) estimation in terms of accuracy and flexibility. An optimal sampling strategy using MAPB estimation is created by either selecting sampling times from a predetermined set of sampling times or using Fisher information to calculate times with the most information on the parameters to be estimated. Validation of the strategy is required, preferably by resampling statistics for its efficient use of data.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7