alexa Optimization of Method for Determination of Swelling Fa
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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Research Article

Optimization of Method for Determination of Swelling Factor of Ispaghula Seeds

Suresh G Killedar*, Harinath More, Sameer Nadaf and Sachin Pishawikar

Bharati Vidyapeeth College of Pharmacy, Chitranagari, Kolhapur, India

Corresponding Author:
Dr. Killedar SG
Bharati Vidyapeeth College of Pharmacy
Chitranagari, Kolhapur-416013, India
Tel: +919730547947
E-mail: [email protected]

Received Date: June 14, 2016; Accepted Date: July 14, 2016; Published Date: July 28, 2016

Citation: Killedar SG, More H, Nadaf S, Pishawikar S (2016) Optimization of Method for Determination of Swelling Factor of Ispaghula Seeds. J Drug Metab Toxicol 7:212. doi: 10.4172/2157-7609.1000212

Copyright: © 2016 Killedar SG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



An endeavour of present study is to optimize the method for determination of swelling factor of Ispaghula seeds, so it can be determined correctly with minimum errors which will be reproducible. The polysaccharides in the mucilage of Plantago seeds constitute a diverse class of biological macromolecules with a broad range of physiochemical properties which are widely used for applications in Pharmacy and medicine. Many official and unofficial sources described different methods for determination of swelling factor with variable results. The present work is undertaken to determine the effect of parameters such as quantity of seed, volume and nature of solvent, time interval of agitation, time of measurement of result, Effect of quantity of seeds on swelling factor determination. Swelling factor of different seeds like Lepodium sativum, Althia officinalis and Occimum sanctum has been evaluated by IP method and optimised method for 24 h. Optimized method gives superlative results over IP method. Plantago seeds moistened with 1ml of 90% alcohol followed by addition of distilled water at room temperature along with every 3 h agitation shows exceptional swelling as compared to other methods and conditions.


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