Optimizing Antibiotic Pharmacodynamics for Clinical PracticeKevin P Connors, Joseph L Kuti* and David P Nicolau
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford Connecticut, USA
- *Corresponding Author:
- Joseph L Kuti
Center for Anti-Infective Research and Development
Hartford Hospital, 80 Seymour Street
Hartford, CT 06102, USA
Tel: (860) 545-3612
E-mail: [email protected]
Received date: January 17, 2013; Accepted date: March 26, 2013; Published date: March 29, 2013
Citation:Connors KP, Kuti JL, Nicolau DP (2013) Optimizing Antibiotic Pharmacodynamics for Clinical Practice.Pharmaceut Anal Acta 4:214. doi: 10.4172/2153-2435.1000214
Copyright: © 2013 Connors KP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
With an absence of new antibiotics in the pipeline to address increasing resistance among gram-positive and gram-negative bacteria, new strategies are needed to retain utilization of currently available agents. As recommended in current guidelines for antimicrobial stewardship, dosage optimization through consideration of antibiotic pharmacodynamics provides a formidable approach to making good antibiotics better. Knowledge of the relationship between antibiotic concentration to microbiological potency and its effect on antibacterial activity leads to the design of dosing regimens that optimize killing of bacteria in the clinical setting. The activity of aminoglycosides is dependent on maximizing peak free drug concentrations in relation to their minimum inhibitory concentration (MIC), so giving larger doses less frequently has become the gold-standard strategy for optimizing their pharmacodynamics. In contrast, the activity of β-lactam antibiotics is dependent on maximizing the time that free drug concentrations remain above the MIC; numerous approaches including continuous and prolonged infusion of these agents enable optimization of this pharmacodynamics parameter and improve clinical outcomes. This review discussed pharmacodynamics concepts as applied clinically for aminoglycosides, β-lactams, and other classes of antibiotics.