alexa Orexin A Controls Glucose Metabolism
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Review Article

Orexin A Controls Glucose Metabolism

Messina G1, Dalia C1, Tafuri D3, Palmieri F1, Dato A1, Russo A1, De Blasio S1, Messina A1, De Luca A2, Chieffi S1 and Monda M1*

1Department of Experimental Medicine, Section of Human Physiology, and Clinical Dietetic Service, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy

2Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

3Faculty of Motor Sciences, University of Naples "Parthenope", Naples, Italy

*Corresponding Author:
Marcellino Monda, MD
Department of Experimental Medicine
Section of Human Physiology, and Clinical Dietetic Service
Second University of Naples, Via Costantinopoli 16
80138 Naples, Italy
Tel: +39 +81 566 5804
Fax: +39 +81 566 7500
E-mail: [email protected]

Received date: May 14, 2014; Accepted date: June 23, 2014; Published date: June 30, 2014

Citation: Messina G, Dalia C, Tafuri D, Palmieri F, Dato A, et al. (2014) Orexin A Controls Glucose Metabolism . J Diabetes Metab 5:398. doi:10.4172/2155-6156.1000398

Copyright: © 2014 Monda M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




The orexin-A and orexin-B are a hypothalamic neuropeptides, involved in the regulation of feeding behaviour, sleep-wakefulness rhythm, and neuroendocrine homeostasis that influence the sympathetic nervous system activity, blood pressure regulation, and metabolic status, glycemic, and may contribute to increase diabetics morbidity and mortality.

This review concentrates on the catabolic role of orexin, which paradoxically coexists with its anabolic feeding-inducing role. This review aims to provide insight into the biological mechanism that controls orexin’s role in energy expenditure and to discuss its significance in the context of glycemic control. On the other hands, hypothalamus regulates muscle glucose metabolism and its insulin sensitivity; in fact the ventromedial hypothalamus increases glucose uptake in certain peripheral tissues, including brown adipose tissue.

The circumstance that it has been found a relationship between brown adipose tissue, orexins, glucose, insulin levels suggests new research focused on the possible roles of orexins in many anomalies of energy expenditure and of glucose homeostasis, with reference to the diabetic patient.


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