alexa Organochlorine Pesticides in the Females Suffering from Breast Cancer and its Relation to Estrogen Receptor Status | OMICS International | Abstract
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication

Organochlorine Pesticides in the Females Suffering from Breast Cancer and its Relation to Estrogen Receptor Status

Madhu Anand1*, Jyoti Singh2, M K J Siddiqui3, Ajay Taneja1, Devendra K Patel4 and Prateek K Mehrotra5

1Department of Chemistry, Institute of Basic Science, Khandari Campus, Dr. B R Ambedkar University, Agra, India

2Amity Institute of Forensic Sciences, Amity University Campus, Sector-125, Noida 201303, India

3Analytical Toxicology, Industrial Toxicology Research Centre, P.O. Box No. 80, M.G. Marg, Lucknow 226 001, India

4Analytical Chemistry, Industrial Toxicology Research Centre, P.O. Box No. 80, M.G. Marg, Lucknow 226 001, India

5Sir Ganga Ram Hospital, New Delhi, India

*Corresponding Author:
Madhu Anand
Department of Chemistry, Institute of Basic Sciences
Khandari Campus Dr. B R Ambedkar University, Agra, India
E-mail: [email protected]

Received date: July 13, 2013; Accepted date: September 28, 2013; Published date: September 30, 2013

Citation: Anand M, Singh J, Siddiqui MKJ, Taneja A, Patel DK, et al. (2013) Organochlorine Pesticides in the Females Suffering from Breast Cancer and its Relation to Estrogen Receptor Status. J Drug Metab Toxicol 4:156. doi: 10.4172/2157-7609.1000156

Copyright: © 2013 Anand M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Breast cancer is one of the most common types of cancer that occurs in females. Approximately 70% of breast tumors express the estrogen receptor. To date, established risk factors for breast cancer are only partially able to explain the causes for this disease. There have always been researchers’ interests in evaluating the role of environmental chemicals, especially those with evidence of being hormonally active agents, which play an important role in breast cancer development. Organochlorine pesticides are one of those chemical which have received the most attentions because of their ability to concentrate onto food chain, fat-soluble and estrogenic activity while remaining persistent in the human body and environment. The present study is an attempt to explore the possibility and role of organochlorine pesticides in the development of estrogen receptor breast cancer. A hospital-based case-control study was administered on 93 women, who underwent various surgeries for breast diseases, to observe the association between organochlorine pesticide exposures with reference to estrogen receptor status in the subjects suffering from breast cancer. Samples of blood, tumor and surrounding adipose tissue of the breast were collected from the subjects with estrogen positive, estrogen negative and benign breast lesions. The samples were then analyzed to determine the presence of organochlorine pesticides by using a gas–liquid chromatography equipped with an electron capture detector. The α, β, γ and δ isomers of HCH (Hexachlorocyclohexane) and metabolites of DDT (Dichlorodiphenyltrichloroethane) such as p,p’-dichlorodiphenyltrichloroethane (p,p-DDT), o,p’- dichlorodiphenyltrichloroethane (o,p’-DDT), p,p’- dichlorodiphenyldichloroethylene (p,p’-DDE), and p,p’-dichlorodiphenyldichloroethane (p,p’-DDD) were frequently detected in the samples at significant level. The result of this study shows that the exposure to potential estrogenic organochlorines may cause the development of estrogen receptor positive breast cancer. A possible mechanism on prognosis of hormone responsive breast cancers needs to be clarified.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7