Organochlorine Pesticides in the Females Suffering from Breast Cancer and its Relation to Estrogen Receptor StatusMadhu Anand1*, Jyoti Singh2, M K J Siddiqui3, Ajay Taneja1, Devendra K Patel4 and Prateek K Mehrotra5
- *Corresponding Author:
- Madhu Anand
Department of Chemistry, Institute of Basic Sciences
Khandari Campus Dr. B R Ambedkar University, Agra, India
E-mail: [email protected]
Received date: July 13, 2013; Accepted date: September 28, 2013; Published date: September 30, 2013
Citation: Anand M, Singh J, Siddiqui MKJ, Taneja A, Patel DK, et al. (2013) Organochlorine Pesticides in the Females Suffering from Breast Cancer and its Relation to Estrogen Receptor Status. J Drug Metab Toxicol 4:156. doi: 10.4172/2157-7609.1000156
Copyright: © 2013 Anand M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Breast cancer is one of the most common types of cancer that occurs in females. Approximately 70% of breast tumors express the estrogen receptor. To date, established risk factors for breast cancer are only partially able to explain the causes for this disease. There have always been researchers’ interests in evaluating the role of environmental chemicals, especially those with evidence of being hormonally active agents, which play an important role in breast cancer development. Organochlorine pesticides are one of those chemical which have received the most attentions because of their ability to concentrate onto food chain, fat-soluble and estrogenic activity while remaining persistent in the human body and environment. The present study is an attempt to explore the possibility and role of organochlorine pesticides in the development of estrogen receptor breast cancer. A hospital-based case-control study was administered on 93 women, who underwent various surgeries for breast diseases, to observe the association between organochlorine pesticide exposures with reference to estrogen receptor status in the subjects suffering from breast cancer. Samples of blood, tumor and surrounding adipose tissue of the breast were collected from the subjects with estrogen positive, estrogen negative and benign breast lesions. The samples were then analyzed to determine the presence of organochlorine pesticides by using a gas–liquid chromatography equipped with an electron capture detector. The α, β, γ and δ isomers of HCH (Hexachlorocyclohexane) and metabolites of DDT (Dichlorodiphenyltrichloroethane) such as p,p’-dichlorodiphenyltrichloroethane (p,p-DDT), o,p’- dichlorodiphenyltrichloroethane (o,p’-DDT), p,p’- dichlorodiphenyldichloroethylene (p,p’-DDE), and p,p’-dichlorodiphenyldichloroethane (p,p’-DDD) were frequently detected in the samples at significant level. The result of this study shows that the exposure to potential estrogenic organochlorines may cause the development of estrogen receptor positive breast cancer. A possible mechanism on prognosis of hormone responsive breast cancers needs to be clarified.