Organophosphate Pesticide Exposure during Pregnancy and Adverse Perinatal Outcome
- *Corresponding Author:
- Shaheen HM
Assistant professor, Department of Family Medicine, Faculty of Medicine
Menoufia University, Al Minufiyah, Egypt
E-mail: [email protected]
Received date: June 14, 2016; Accepted date: October 17, 2016; Published date: October 25, 2016
Citation: Farahat T, Shaheen HM, Sanad Z, Farag NA (2016) Organophosphate Pesticide Exposure during Pregnancy and Adverse Perinatal Outcome. J Women's Health Care 5:336. doi:10.4172/2167-0420.1000336
Copyright: © 2016 Shaheen HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Little is known about potential adverse health effects of in utero exposure to organophosphate (OP) pesticides. The aim of this study was to assess the effect of organophosphate pesticide exposure during pregnancy and adverse perinatal outcome. Subject and Methods: This prospective study was conducted during the period from March 2013 to March 2105 and included two groups of pregnant women, 40 exposed women and 100 unexposed women as a control group. Both groups were matched for age, socioeconomic class educational level and body mass index. Serum acetyl cholinesterase (AChE) was measured in all participants at 20-22 weeks’ gestation. All women were followed up till delivery. Perinatal outcome was assessed in terms of gestational age at delivery, birth weight, head circumference and body length of the newborn. Results: Exposed participants exhibited significantly shortened gestational age, low birth weight and smaller head circumference than controls. There was a positive correlation between reduced level of AChE and gestational age and birth weight. Conclusions: Our results confirmed the association between organophosphate pesticide exposure during pregnancy and adverse perinatal outcome in terms of reduced gestational age, low birth weight and small head circumference.