alexa Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors Central and Peripheral Types in the Cerebral Cortex of Heavy Drinkers Rats
ISSN: 2329-6488

Journal of Alcoholism & Drug Dependence
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors Central and Peripheral Types in the Cerebral Cortex of Heavy Drinkers Rats

TV Shushpanova1*, AV Solonskii1, NA Bokhan1, TP Novozheeva1, VV Udut2, GA Arbit3 and VD Filimonov3

1Department of Clinical Neuroimmunology and Neurobiology, Mental Health Research Institute, Russia

2Department of Molecular and Clinical Pharmacology, Research Institute of Pharmacology and Regenerative Medicine, Russia

3Department of Biotechnology and Organic Chemistry, National Research Tomsk Polytechnic University, Russia

Corresponding Author:
Tamara Shushpanova
Mental Health Research Institute 4 Aleutskaya Street, Tomsk 634014, Russia
Tel: +7923-440-3320
Fax: +7382-272-4425
E-mail: [email protected]; [email protected]

Received date: February 19, 2016; Accepted date: April 08, 2016; Published date: April 12, 2016

Citation: Shushpanova TV, Solonskii AV, Bokhan NA, Novozheeva TP, Udut VV, et al. (2016) Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors “Central” and “Peripheral” Types in the Cerebral Cortex of “Heavy Drinkers” Rats. J Alcohol Drug Depend 4:234. doi:10.4172/2329-6488.1000234

Copyright: © 2016 Shushpanova TV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: studies of anticonvulsants have a stimulating effect on neuronal receptors; in particular GABAA/ benzodiazepine receptor complex (GABAA/BzDR) can be the basis for the development of new approaches to the treatment of alcohol withdrawal syndrome (AWS) and alcohol addiction. Benzodiazepine receptors (BzDRs) of the cerebral cortex of Wistar male rats with a different preference for alcohol and BzDRs in the brain “heavy drinkers” rats, treated with original anticonvulsant meta-chloro-benzhydryl urea (m-ch-BHU) were examined in these study.

Materials and methods: Wistar male rats (n=250) were used in an experimental model of alcoholism. Properties of the BzDRs of the “central” (synaptic) and “peripheral” (mitochondrial) type were examined in membrane fractions obtained from the cerebral cortex of rats under various experimental groups using radio receptor binding assays (RRA) selective ligands: [3H]flunitrazepam and [3H] Ro5-4864 to these receptors respectively.

Results: our study has shown that the binding affinity of [3H] flunitrazepam and [3H] Ro5-4864 with synaptosomal and mitochondrial membranes was decreased, but capacity of receptors was increased in the cerebral cortex of rats prefer alcohol. Administration of m-ch-BHU increased affinity of BzDRs in the cortex of “heavy drinkers” rats that can enhance the mediation of GABA in the brain of these animals.

Conclusion: Our data showed that m-ch-BHU has a stimulating effect on GABAA/BzDRs in the brains of “heavy drinkers” rats and may provide a new pharmacotherapeutic approach to the treatment of alcohol addiction.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords