alexa Original Covalent Approach for Gold Nanorods Immobiliza
ISSN: 2155-6210

Journal of Biosensors & Bioelectronics
Open Access

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Research Article

Original Covalent Approach for Gold Nanorods Immobilization onto Acid-Terminated-Cysteamine Self-Assembled Monolayers for FT-SPR Biosensor Applications

Politi J1,2, De Stefano L2, Casale S3 and Spadavecchia J3,4*

1Department of Chemical Sciences, University of Naples, Italy

2Institute for Microelectronics and Microsystems, Unit of Naples-National Research Council, Italy

3Laboratoire de Réactivité de Surface, UMR CNRS 7197, Université Pierre and Marie Curie-Paris VI, France

4CNRS, UMR 7244, CSPBAT, Laboratoire de Chimie, Structures et Propriétés de Biomateriaux et d’Agents Therapeutiques Université Paris 13, Sorbonne Paris Cité, Bobigny, France CNRS, Paris, France

*Corresponding Author:
Spadavecchia J
Laboratoire de Réactivité de Surface
Université Pierre and Marie Curie–Paris VI
Site d’Ivry–Le Raphaël
94200 Ivry-sur-Seine, France
Tel : 33 4 37 42 35
E-mail: [email protected]

Received Date: May 05, 2015 Accepted Date: June 10, 2015 Published Date: June 20, 2015

Citation: Politi J, Stefano LD, Casale S, Spadavecchia J (2015) Original Covalent Approach for Gold Nanorods Immobilization onto Acid-Terminated-Cysteamine Self-Assembled Monolayers for FT-SPR Biosensor Applications. J Biosens Bioelectron 6:167. doi: 10.4172/2155-6210.1000167

Copyright: © 2015 Politi J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In this paper, we report an original method to immobilize gold nanorods onto mixed self-assembled monolayers (SAMs) of Mercaptoundecanoic Acid (MUA), Mercaptohexanol (MOH) and cysteamine (CYS) onto planar gold surface. Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images revealed a remarkable shape and size narrow distribution on well functionalized gold surfaces, as well as a tendency to form linear assemblies after immobilization. The results highlight the good distribution of gold nanorods with an average length of 32.6 ± 0.9 nm and width of 13 ± 1.8 nm, the simplicity of the immobilization procedure of gold nanorods and the interest of using them as labels to enhance the sensitivity of FT-SPR-based sensors. gold nanostructured surface FT-SPR measurements of biorecognition using gold nanorods immobilized onto gold surfaces were performed at various prostatic antigen specific (PSA) concentrations, from 5 mg/L to 0.5 mg/L reaching a system sensitivity of 37 ± 2 cm-1/ mgL-1.


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