Oscillator Suppression in the Blood Flow Regulation of Interacting, Non- Identical Nephrons
- *Corresponding Author:
- Yulia P Emelianova
Institute of Electronics and Mechanical Engineering
Yuri Gagarin State Technical University of Saratov
Polytechnicheskaya 77, 410054 Saratov, Russia
E-mail: [email protected]
Received Date: April 25, 2014; Accepted Date: May 28, 2014; Published Date: May 30, 2014
Citation: Emelianova YP, Kuznetsov AP, Laugesen JL, Mosekilde E, Holstein-Rathlou NH (2014) Oscillator Suppression in the Blood Flow Regulation of Interacting, Non-Identical Nephrons. J Hypertens 3:153. doi:10.4172/2167-1095.1000153
Copyright: © 2014 Emelianova YP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Regulation of the blood flow to the individual functional unit (nephron) of the kidney involves a feedback mechanism that produces large-amplitude oscillations in the blood flow itself as well as in the intra-nephron pressures and flows. Neighboring nephrons adjust their blood flow variations relative to one another via signals that propagate along the interconnecting blood vessels.
Purpose and method: Using a detailed physiological-based model of a pair of vascular coupled, non-identical nephrons, the paper examines the effect that their relative oscillatory strength has on the behavior of the coupled system. This is of direct interest in connection with ongoing work attempting to study the synchronization behavior for larger groups of superficial nephrons by means of laser speckle contrast imaging.
Results: Our analysis demonstrates that a region of so-called “broadband Synchronization” may develop between those coupling strengths at which the stronger oscillating nephron starts to suppress the autonomous oscillations of the weaker nephron and those coupling strengths at which the two nephrons mutually inhibit each other’s oscillations. We suggest that the transition be-tween synchronized and suppressed dynamics may have a physiological significance comparable to the transition from ergodic to synchronized periodic dynamics.