Outcome of Capparis Spinosa Fruit Extracts Treatment on Liver, Kidney, Pancreas and Stomach Tissues in Normal and Diabetic RatsMohammad Mohsen Taghavi1, Mahmood Nazari2, Rasoul Rahmani2, Ahmadreza Sayadi3, Mohammad Reza Hajizadeh2,4, Mohammad Reza Mirzaei2,4, Hassan Ziaaddini5, Seyed Mostafa Hosseini-Zijoud6 and Mehdi Mahmoodi2,4*
- *Corresponding Author:
- Mahmoodi M
Molecular Medicine Research Center and Department of Clinical Biochemistry
Faculty of Medicine, Rafsanjan University of Medical Sciences
Tel: 0098913 191 4855
Fax: 0098391 522 5209
E-mail: [email protected]
Received date: June 18 2014; Accepted date: October 10, 2014; Published date: October 13, 2014
Citation: Taghavi MM, Nazari M, Rahmani R, Sayadi A, Hajizadeh MR, et al. (2014) Outcome of Capparis Spinosa Fruit Extracts Treatment on Liver, Kidney, Pancreas and Stomach Tissues in Normal and Diabetic Rats. Med chem 4:717-721. doi:10.4172/2161-0444.1000218
Copyright: © 2014 Taghavi MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aim and objectives: Herbal drugs such as, Capparis Spinosa (CS) has been used to treat several diseases from heart and cardiovascular disorders to diabetes in traditional Iranian medicine. The present study was aimed to determine beneficiary effects of CS fruit extract on a number of tissues in healthy and type 1 diabetic rat.
Materials and methods: In this experimental study, sixty male wistar rats were randomly divided into 6 groups (n=10) and subjected to gavage tube therapy for one months by following protocol: group I and IV: diabetic control and non-diabetic control rats which only received distilled water; groups II and III: non diabetic treatment rats which received 200 mg/kg and 800 mg/kg CS extract per day respectively; groups V and VI: diabetic treatment rats which received 200 mg/kg and 800 mg/kg CS extract per day respectively. Diabetes was induced by intra-peritoneal injection of 50 mg/kg of streptozotocin (STZ). After 4 weeks, their blood were collected and the serum levels of creatinine, bilirubin, urea, uric acid, AST, ALT and ALP were measured. The liver, kidney, pancreas and stomach tissues were immediately excised, and after slide preparation processes, the histological changes were studied.
Results: Our results illustrated that the gastric tissue in the diabetic group showed a small degree of changes and was not affected significantly by administration of the CS fruit extract. Liver, pancreas and kidney of diabetic rats exhibited considerable changes, like cellular necrosis. These changes in diabetic treatment groups were at lowest amounts. The decrease levels of creatinine, liver enzymes, and other factors were supporting these changes.
Conclusions: This study demonstrates that the CS fruit extract could be aid prevention of damage to the tissues due to the decreased levels of harmful oxidants in the body in diabetes. Moreover, according to our previous results altogether we showed beneficial impact of the plant on the treatment of diabetes.