alexa Outpatient Antibiotic Prescription in the South of Port

Research & Reviews: Journal of Hospital and Clinical Pharmacy
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Research Article

Outpatient Antibiotic Prescription in the South of Portugal

Isabel Maria Pires Sebastião Ramalhinho1* ,Carlos Alberto dos Santos Filipe2,Luís Filipe Ribeiro de Almeida Gomes2,Afonso Miguel das Neves Cavaco3,4, José Joaquim Cabrita da Silva2,4

Faculty of Science and Technology, University of Algarve, Faro, Portugal

Administração Regional de Saúde do Algarve, Portugal

Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL) Faculty of Pharmacy, University of Lisbon, Portugal

Faculty of Pharmacy, University of Lisbon, Portugal

*Corresponding Author:
Isabel Ramalhinho
Faculty of Science and Technology, University of Algarve
Campus de Gambelas, 8005-139 Faro Portugal
Tel: 351 289800066
E-mail: [email protected]

Received date: 04/12/2015 Accepted date: 20/01/2016 Published date: 25/01/2016



Background: Antibiotic abuse and misuse are recognized as important determinants for bacterial antibiotic resistance. Although there are frequent calls to stop the unnecessary use of antibiotics, both consumption and resistance are escalating over the world. Objective: To assess the antibiotic prescription and its determinants in the Algarve, for different infectious diseases in Primary Care. Method: A Drug Use Study (Prescription-Indication Study) was performed in a convenience sample of 70 general practitioners (GPs) working in the Algarve (Portugal). During the study period each GP consecutively selected 20 patients with an antibiotic prescription for systemic use, characterizing their clinical and therapeutic profiles. Results: About 81% (57/70) of the invited GPs returned the requested data. A total of 925 patients were included in the study, 40% of them male. Patients’ mean age was 41.4 years (range: 1 to 94; SD=24.14). Respiratory (50.5%) and urinary tract infections (29.8%) were the infectious conditions more frequently treated, accounting for 80.3% of the total. Penicillins were the antibiotics most prescribed (43.7%), followed by macrolides (20.15%) and quinolones (19.3%), the last two preferably prescribed by older GPs. For respiratory infections, younger GPs prescribed penicillins more frequently (62.1%) than other GPs. While treating the same infections, female GPs prescribed significantly more macrolides (40.5%) than males (29.6%). Conclusion: Considering the costs, side effects and growth of bacterial resistance, it is important to improve antibiotic prescribing as much as possible. Developing effective interventions to reduce inappropriate antibiotic prescribing will require a clear understanding of the predictors that influence the prescribing behaviour.


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