alexa Ovarian Cancer Recurrence: Role of Ovarian Stem Cells a
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Review Article

Ovarian Cancer Recurrence: Role of Ovarian Stem Cells and Epithelial-to-Mesenchymal Transition

Ricci F, Guffanti F and Damia G*
Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Corresponding Author : Giovanna Damia
Department of Oncology
IRCCS-Mario Negri Institute for Pharmacological Research
Via La Masa 19, 20156 Milan, Italy
Tel: +39 02 3901 4234
Fax: +39 02 3901 4734
E-mail: [email protected]
Received June 20, 2014; Accepted August 20, 2014; Published August 25, 2014
Citation: Ricci F, Guffanti F, Damia G (2014) Ovarian Cancer Recurrence: Role of Ovarian Stem Cells and Epithelial-to-Mesenchymal Transition. J Cancer Sci Ther 6:298-305. doi:10.4172/1948-5956.1000284
Copyright: © 2014 Ricci F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Despite the remarkable progress made in delineating the pathogenesis of ovarian tumor during the last two decades, the 5 years survival of these patients is very low, with 80% of them succumbing to their resistant disease. Understanding the key determinants of this resistance is of paramount importance if the prognosis of this tumor has to be improved. Here are summarized the role of cancer stem cells and epithelial to mesenchymal transition (EMT) in determining tumor recurrence in ovarian cancer. Indeed, the existence, and more importantly the acquisition of stem-cell traits by tumor cells both during tumor progression and during treatment might explain the ability of these cells to give rise to tumor recurrence and to be resistant to treatment.

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