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Overcoming the Deficiency of Singular Detection by Antibody Arrays in Cancer Biomarker Discovery | OMICS International | Abstract
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

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Review Article

Overcoming the Deficiency of Singular Detection by Antibody Arrays in Cancer Biomarker Discovery

Weidong Jiang1 and Ruo-Pan Huang1,2*

1RayBiotech Inc, Norcross, GA 30092, USA

2RayBiotech Inc, Guangzhou, 510600, China

*Corresponding Author:
Ruo-Pan Huang
RayBiotech Inc, 3607 Parkway Lane
Suite 200, Norcross, GA 30092, USA
E-mail: [email protected]

Received date: October 21, 2011; Accepted date: August 27, 2012; Published date: August 30, 2012

Citation: Jiang W, Huang RP (2012) Overcoming the Deficiency of Singular Detection by Antibody Arrays in Cancer Biomarker Discovery. J Mol Biomark Diagn 3:132. doi:10.4172/2155-9929.1000132

Copyright: © 2012 Jiang W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Since cancer is a heterogeneous disease, it is unlikely that a single biomarker will detect all cancers of a particular organ with high specificity and sensitivity. Thus, detection of expression of multiple proteins is essential to unraveling the mechanisms and effects of carcinogenesis. Antibody arrays have been developed to meet this growing demand. The ability to simultaneously measure the expression profiling of multi-protein markers will provide a powerful platform for identification of new cancer biomarkers. In this review, we will discuss the planar format of antibody array technology, its suitability and challenges for cancer biomarker discovery, and examples of its applications for biomarker discovery and validation in a wide variety of human cancers

Keywords

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