alexa Overexpression of Pro-Inflammatory Cytokines in Myelody
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Research Article

Overexpression of Pro-Inflammatory Cytokines in Myelodysplastic Syndrome (MDS-RA)

Natarajan Venkateswaran1*, Perumal Venkatachalam1, Venkatesan Vettriselvi1, Solomon FD Paul1, Usha Nair2, Margaret Chellaraj2 and Dominic F Joseph3
1Faculty of Biomedical Sciences, Sri Ramachandra University, Chennai, India
2Department of Hematology, Government General Hospital, Chennai, India
3Department of HematoOncology, Dr. Kamakshi Memorial Hospital, Chennai, India
Corresponding Author : Dr. Venkateswaran Natarajan
Diagnostic Medical Oncology Centre
Department of Pathology, National University Hospital(S) Pte Ltd
Lower Kent Ridge Road, Singapore-119074
Tel: +65 97515219
E-mail: [email protected]
Received: December 15, 2015; Accepted: January 19, 2016; Published: January 26, 2016
Citation: Venkateswaran N, et al. (2016) Overexpression of Pro-Inflammatory Cytokines in Myelodysplastic Syndrome (MDS-RA). J Hematol Thrombo Dis 4:231. doi:10.4172/2329-8790.1000231
Copyright: © 2016 Venkateswaran N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: Myelodysplasia comprises a heterogenous group of disorder characterized by ineffective hematopoiesis and extensive apoptosis of hematopoietic cells. Although previous studies revealed few cytogenetic and molecular abnormalities, the underlying defect in the molecular pathway for extensive apoptosis and dysplasia observed in the disease is yet to be identified. This study aims to evaluate the pro-inflammatory cytokines and transcription factors levels in the refractory anemia subset of myelodysplasia (MDS-RA). The study evaluated bone marrow aspirates from 35 MDS-RA and 10 leukemic cases. All samples were analyzed for the rate of apoptosis, levels of various pro-inflammatory cytokines such as TNF-α, TNF receptors, TGF-β, Fas, IFN-γ and transcription factor NFκB that moderates the apoptotic pathway, were estimated by quantitative PCR. Results: Increased apoptosis in conjunction with significantly elevated cytokines levels of all the three subtypes of TGF-β1, TGF-β2, TGF-β3, TNF-α in MDS-RA samples. TNFR1 and TNFR2 (p<0.05) expression were significantly increased in MDS-RA than the leukemia group along with the Fas and INF-γ. Expressions of transcription factor subtypes NFκB1, NFκB2 and NFκB3 were observed significantly high (p<0.05) in MDS-RA compared to leukemia group. Conclusion: The findings of the study imply a defective signaling of pro-inflammatory cytokines and transcriptional factor NFκB pathway attributing to extensive apoptosis in early MDS. Highly deregulated cytokine signaling in the bone marrow samples of MDS contributes to the extensive apoptosis and also, a possible hematopoietic arrest resulting in refractory anemia. In addition, the dysregulation of cytokine expression contributes to genomic alteration resulting in MDS progression to acute myeloid leukemia (AML).

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