alexa Over-Expressions of Serum miR-182-5p, miR-363-3p, and m
ISSN: 2168-9547

Molecular Biology: Open Access
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Research Article

Over-Expressions of Serum miR-182-5p, miR-363-3p, and miR-378a-3p serve as Biomarkers in Hepatocellular Carcinoma

Siquan Zhang1, Liming Zhu2, Huafeng Liu1, Shourong Liu1, Nianbo Zhao1, Jing Wu1, Xiaoxiao Huang1, Yujuan Zhang1, Jie Jin1, Dajing Wang2, Zhiguo Zheng3* and Xianfeng Ding2*

1Xixi Hospital of Hang Zhou, Hangzhou 310023, China

2College of Life Science, Zhejiang Sci-Tech University, Hangzhou10018, China

3Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou 310022, China

*Corresponding Author:
Zhiguo Zheng
Zhejiang Cancer Research Institute
Zhejiang Cancer Hospital
Hangzhou 310022, China
Tel: +86-571-88122421
E-mail: [email protected]
 
Xianfeng Ding
Zhejiang Cancer Research Institute
Zhejiang Cancer Hospital
Hangzhou 310022, China
Tel: +86-571-88122421
E-mail: [email protected]

Received date: December 09, 2015; Accepted date: January 18, 2016; Published date: January 25, 2016

Citation: Zhang S, Zhu L, Liu H, Liu S, Zhao N, et al. (2016) Over-Expressions of Serum miR-182-5p, miR-363-3p, and miR-378a-3p serve as Biomarkers in Hepatocellular Carcinoma. Mol Biol 5:154. doi: 10.4172/2168-9547.1000154

Copyright: © 2016 Zhang S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Serum α-fetoprotein (AFP) has been used as an early diagnostic biomarker of hepatocellular carcinoma (HCC), however the sensitivity and specificity of detection are poor. Therefore, new markers remain to be explored. MicroRNAs (miRNAs) are a class of small RNAs which could contribute to tumorigenesis by interaction with targeted mRNAs. MiRNAs are abundant in the circulating blood and are potentially useful for early diagnosis of hepatocellular carcinoma. In this study, we screened a group of candidate miRNAs (miR-182-5p, miR-363-3p, and miR-378a-3p) in serum, which were found to be up-regulated in HCC patients compared with in the healthy controls. Analysis of the receiver operating characteristic (ROC) curve suggested that these three serum miRNAs had merits in the diagnosis of HCC (AUC=0.802, 0.845, 0.880, respectively). Furthermore, these candidate miRNAs can also differentiate HCC patients with negative AFP level from the healthy controls (AUC=0.865, 0.930, 0.970, respectively). In conclusion, our results suggested that serum miR-182-5p, miR-363-3p, and miR-378a-3p might be applied as potential non-invasive biomarkers for HCC diagnosis, which is especially important for AFP-negative patients.

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