alexa Overview of IgG-Reactivity in Therapeutic immunoglobulins Revealed by Protein Array Analysis
ISSN: 2161-1009

Biochemistry & Analytical Biochemistry
Open Access

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Research Article

Overview of IgG-Reactivity in Therapeutic immunoglobulins Revealed by Protein Array Analysis

Sonia Néron1,2* and Annie Roy1
1Héma-Québec, Ingénierie cellulaire, Recherche et Développement, 1070 avenue des Sciences-de-la-vie, Québec, Québec, Canada, G1V 5C3
2Université Laval, Faculté des sciences et de génie, Département de Biochimie et Microbiologie, 1045 avenue de la Médecine, Québec, Québec,Canada, G1V 0A6
Corresponding Author : Sonia Néron
Héma-Québec, Recherche et Développement
1070 avenue des Sciences-de-la-vie
Québec (Québec), Canada, G1V 5C3
Tel:1 (418) 780-4362 (ext. 3260)
Fax: 1 (418) 780-2091
E-mail: [email protected]
Received May 17, 2012; Accepted July 23, 2012; Published July 26, 2012
Citation: Néron S, Roy A (2012) Overview of IgG-Reactivity in Therapeutic immunoglobulins Revealed by Protein Array Analysis. Biochem Anal Biochem S8:001. doi: 10.4172/2161-1009.S8-001
 
Copyright: ©2012 Néron S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 
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Abstract

In addition to therapy for immune deficient patients, intravenous immune globulins (IVIg) are used to treat several autoimmune and inflammatory diseases. Several groups working to better understand how IVIg can modulate immune and inflammatory responses have proposed the involvement of self-reactive IgG present in IVIg. Consequently, a moreexhaustive characterization of IVIg repertoire could be very helpful for their better utilization. To increase our knowledge on IVIg repertoire, we have used the technology of protein array analysis to characterize a commercial IVIg preparation by screening its interaction with 9484 proteins of human origin. As a result, we have identified 67 proteins, which are strongly recognized by the IgG present in IVIg. Most of these targets are highlighted for the first time bringing new insight into IVIg mechanisms of action.

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