alexa Oxidants in Acute and Chronic Lung Disease | OMICS International
ISSN: 2165-7831

Journal of Blood & Lymph
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Review Article

Oxidants in Acute and Chronic Lung Disease

Praveen Mannam1*, Anup Srivastava1, Jaya Prakash Sugunaraj2, Patty J Lee1 and Maor Sauler1

1Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA

2Pulmonary and Critical Care Medicine, Geisinger Medical center, PA, USA

*Corresponding Author:
Praveen Mannam
Department of Internal Medicine
Yale University School of Medicine
300 Cedar Street, USA
Tel: 2037374162
Fax: 203-785-3826
E-mail: [email protected]

Received Date: July 28, 2014; Accepted Date: September 9, 2014; Published Date: September 11, 2014

Citation: Praveen Mannam, Anup Srivastava, Jaya Prakash Sugunaraj, Patty J Lee, Maor Sauler (2014) Oxidants in Acute and Chronic Lung Disease. J Blood Lymph 4:128. doi: 10.4172/2165-7831.1000128

Copyright: © 2014 Mannam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Oxidants play an important role in homeostatic function, but excessive oxidant generation has an adverse effect on health. The manipulation of Reactive Oxygen Species (ROS) can have a beneficial effect on various lung pathologies. However indiscriminate uses of anti-oxidant strategies have not demonstrated any consistent benefit and may be harmful. Here we propose that nuanced strategies are needed to modulate the oxidant system to obtain a beneficial result in the lung diseases such as Acute Lung Injury (ALI) and Chronic Obstructive Pulmonary Disease (COPD). We identify novel areas of lung oxidant responses that may yield fruitful therapies in the future.

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