Reach Us +447480022765
Oxidative Stress and Therapeutic Development in Lung Diseases | OMICS International | Abstract
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Oxidative Stress and Therapeutic Development in Lung Diseases

Leah Villegas1,2, Timothy Stidham1 and Eva Nozik-Grayck1,2*

1Department of Pediatrics, University of Colorado, Aurora, CO, 80045, USA

2Cardiovascular Pulmonary Research, University of Colorado, Aurora, CO, 80045, USA

*Corresponding Author:
Eva Nozik-Grayck
University of Colorado, Anschutz Medical Campus
12700 E. 19th Ave, B131, Aurora, CO 80045, USA
Tel: (303) 724-5615
Fax: (303) 724-5617
E-mail: [email protected]

Received date: March 31, 2014; Accepted date: July 11, 2014; Published date: July 15, 2014

Citation: Villegas L, Stidham T, Nozik-Grayck E (2014) Oxidative Stress and Therapeutic Development in Lung Diseases. J Pulm Respir Med 4:194. doi:10.4172/2161-105X.1000194

Copyright: © 2014 Villegas L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Oxidative stress has many implications in the pathogenesis of lung diseases. In this review, we provide an overview of Reactive Oxygen Species (ROS) and nitrogen (RNS) species and antioxidants, how they relate to normal physiological function and the pathophysiology of different lung diseases, and therapeutic strategies. The production of ROS/RNS from endogenous and exogenous sources is first discussed, followed by antioxidant systems that restore oxidative balance and cellular homeostasis. The contribution of oxidant/antioxidant imbalance in lung disease pathogenesis is also discussed. An overview of therapeutic strategies is provided, such as augmenting NO bioactivity, blocking the production of ROS/RNS and replacement of deficient antioxidants. The limitations of current strategies and failures of clinical trials are then addressed, followed by discussion of novel experimental approaches for the development of improved antioxidant therapies.


Recommended Conferences
Share This Page