Oxidative Stress and Therapeutic Development in Lung DiseasesLeah Villegas1,2, Timothy Stidham1 and Eva Nozik-Grayck1,2*
- *Corresponding Author:
- Eva Nozik-Grayck
University of Colorado, Anschutz Medical Campus
12700 E. 19th Ave, B131, Aurora, CO 80045, USA
Tel: (303) 724-5615
Fax: (303) 724-5617
E-mail: [email protected]
Received date: March 31, 2014; Accepted date: July 11, 2014; Published date: July 15, 2014
Citation: Villegas L, Stidham T, Nozik-Grayck E (2014) Oxidative Stress and Therapeutic Development in Lung Diseases. J Pulm Respir Med 4:194. doi:10.4172/2161-105X.1000194
Copyright: © 2014 Villegas L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Oxidative stress has many implications in the pathogenesis of lung diseases. In this review, we provide an overview of Reactive Oxygen Species (ROS) and nitrogen (RNS) species and antioxidants, how they relate to normal physiological function and the pathophysiology of different lung diseases, and therapeutic strategies. The production of ROS/RNS from endogenous and exogenous sources is first discussed, followed by antioxidant systems that restore oxidative balance and cellular homeostasis. The contribution of oxidant/antioxidant imbalance in lung disease pathogenesis is also discussed. An overview of therapeutic strategies is provided, such as augmenting NO bioactivity, blocking the production of ROS/RNS and replacement of deficient antioxidants. The limitations of current strategies and failures of clinical trials are then addressed, followed by discussion of novel experimental approaches for the development of improved antioxidant therapies.