Oral Health and Dental Management

Abstract

Oxidative Stress Evaluation During Perimplantar Bone Resorption in Immediate Post-Extractive Implant

Boccellino Mariarosaria, D'Amato Salvatore, Lama Stefania, Bitti Giuseppe, De Maria Salvatore, Ravagnan Gianpietro, Itro Angelo, Stiuso Paola

Background and purpose: The pathological events, caries, periodontitis and trauma, leading to the destruction and loss of tooth and periodontium are representing complex interactions involving an excessive osteoclastic activity. The osteoclasts can especially produce reactive oxygen species (ROS) that may be involved in the pathogenesis of periodontal disease and development of several inflammatory oral pathologies. The polydatin, a natural precursor of resveratrol, could be used as adjuncts to counteract plaqueassociated bacteria and inflammatory diseases of oral cavity. Aim: 1) to relate the perimplantar bone resorption to lipid peroxidation and systemic inflammation in patients subjected to implant integration, 2) to value the future prospect of an antioxidant polydatin therapy that may decreases the bone perimplantar resorption due to oxidative stress. Methods: Fifteen patients (implant-group) receiving treatment with immediate single post-extractive implants. In relation to the sockets forms, periodontal biotype, the titanium implants was selected to obtain immediate tooth loss restoration. The bone implant integration was monitored by radiographic examinations and the saliva samples were drawn in different times during the entire process and performed to NO, MDA assay and inflammatory enzyme. Results: we have observed an increase, during implant integration between the first and third week, of both oxidative stress markers and cyclooxygenase-2 expression. At sixteen week the parameters evaluated returned to basal values. The oxidative stress and inflammatory markers could be used to evaluate the implant bone-integration. Furthermore our data showed that polydatin has both antibacterial and antioxidant activity and it could represent a adjuvants for bone perimplantar resorption.