Oxidative Stress in Bipolar Disorder
- *Corresponding Author:
- Jun-Feng Wang
Department of Pharmacology & Therapeutics
University of Manitoba, 406 - 753 McDermot Ave
Winnipeg, Manitoba R3E OE3, Canada
E-mail: [email protected]
Received Date: November 08, 2012; Accepted Date: December 17, 2012; Published Date: December 19, 2012
Citation: Tang V, Wang JF (2012) Oxidative Stress in Bipolar Disorder. Biochem Anal Biochem S2:002. doi:10.4172/2161-1009.S2-002
Copyright: © 2012 Tang V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Research on the complex and multifaceted nature of Bipolar Disorder (BD) pathophysiology has recently expanded to include oxidative stress. Several lines of evidence have reported higher reactive oxygen species production that results in increased oxidative damage in proteins, lipids, and nucleic acids. These findings have been observed in brains and peripheral samples of BD patients, as well as being reproduced in a number of animal model studies. Also discussed in this review is research highlighting antioxidant properties of existing mood stabilizing drugs, with consideration paid to novel therapeutic treatments for BD through the alleviation of oxidative stress. The maladaptive oxidative modifications of cellular macromolecules may be associated with impaired neuroplasticity and the development of functional abnormalities in the brain.