alexa p53 and the PWWP Domain Containing Effector Proteins in
ISSN: 2168-9296

Cell & Developmental Biology
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Review Article

p53 and the PWWP Domain Containing Effector Proteins in Chromatin Damage Repair

Jing Hu and Yanming Wang*
Graduate Program in Biochemistry and Molecular Biology, Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, USA
*Corresponding Author : Yanming Wang
Graduate Program in Biochemistry and Molecular Biology
Center for Eukaryotic Gene Regulation
Department of Biochemistry and Molecular Biology
Pennsylvania State University, University Park, PA, 16802 USA
E-mail: [email protected]
Received April 16, 2013; Accepted May 07, 2013; Published May 10, 2013
Citation: Hu J, Wang Y (2013) p53 and the PWWP Domain Containing Effector Proteins in Chromatin Damage Repair. Cell Dev Biol 2:112. doi:10.4172/2168-9296.1000112
Copyright: © 2013 Hu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In eukaryotic cells, DNA damage repair occurs on a template DNA that is organized with histones to form nucleosomes and chromatin structures. As such, chromatin plays an important role in DNA damage repair. In this review, we will use “chromatin damage repair” as a framework and highlight recent progress in understanding the role of chromatin, chromatin modifiers, chromatin binding effectors (e.g., the PWWP domain proteins), and the p53 tumor suppressor. We view chromatin as an active participant during DNA damage repair.

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