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p53-Cells' Inbuilt Mechanism to Inhibit Cancer through Apoptosis | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Review Article

p53-Cells' Inbuilt Mechanism to Inhibit Cancer through Apoptosis

Rashmi Kumariya1*, Amit K. Barui2# and Smita Singh2#

1Animal Biochemistry, Division National Dairy Research Institute, Karnal, Haryana, India

2Dairy Chemistry, Division National Dairy Research Institute, Karnal, Haryana, India

#These athurs are contributed equally

*Corresponding Author:
Rashmi Kumariya
Animal Biochemistry Division
National Dairy Research Institute, Karnal, Haryana-132001, India
E-mail: [email protected]

Received date: September 24, 2012; Accepted date: October 17, 2012; Published date: October 19, 2012

Citation: Kumariya R, Barui AK, Singh S (2012) p53-Cells’ Inbuilt Mechanism to Inhibit Cancer through Apoptosis. J Cancer Sci Ther 4: 368-370. doi:10.4172/1948-5956.1000169

Copyright: © 2012 Ibrahim AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Cancer cells continue to grow and divide, without undergoing apoptosis. p53, a tumor suppressor protein, serves as a checkpoint in prevention of cancer by inducing the abnormal cells to commit apoptosis. p53 can induce both extrinsic and intrinsic pathways of apoptosis and can also induce apoptosis by directly acting on mitochondria. Regulation of p53 concentration in cell is very critical and is regulated by Mdm2 which triggers degradation through ubiquitinylation. Keeping in view, the role of p53 in preventing cancer, many effective strategies can be developed to combat cancer by enhancing either function or stability of p53.

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