Abstract

Objective: To investigate the clinic pathologic features, diagnosis, differential diagnosis, treatment and prognosis of the pancreatic acinar cell carcinoma.
Methods: The clinical data, pathomorphology and immunohistochemical staining of one patient case of Pancreatic cell carcinoma with liver involvement treated by Pancreaticoduodenectomy and partial hepatectomy at the first Affiliated Hospital of Anhui Medical University in April 2016 was analyzed retrospectively.
Results: Iconography scan of the abdomen or the whole body demonstrated a pancreatic mass and liver masses, with celiac Lymph node enlargement in a 58-years old female.
Microscopic examination showed that the pancreatic and liver tumor cells were trabecular and micro-glandular arrangement by biopsy; tumor cells were round or polygonal, and cytoplasm was rich, eosinophilic and granular, and some parts were vesicular, nuclei were mostly located in the base and round and oval; a large number of eosinophil’s were found in the interstitial infiltrating, rich eosinophilic granules were also found in their cytoplasm, and nuclei were slightly atypia
Immuno-histochemical staining showed that tumor cells were CgA (-), α-ACT (+), NSE (+/-) Ki-67 (index about 15%) and Syn (-).
Conclusion: Although acinar cell carcinoma of the pancreas has distinct characteristics on imaging and elevated AFP, correct diagnosis was difficult to determine preoperatively according image logical and laboratory examination. We should consider pancreatic cancer in the differential diagnosis of similar cases.

Keywords: Acinar cell carcinoma; Pancreas; Pathology; Clinical; Immunohistochemistry