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ISSN: 2376-0389

Journal of Multiple Sclerosis
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Research Article

Pain in Multiple Sclerosis: Prevalence and Characteristics of Various Pain Conditions

Sona Feketova*

Neurologická klinika, Nemocnica Staré Mesto Mickiewiczova 13, 813 69 Bratislava, Slovakia

*Corresponding Author:
Sona Feketova
Neurologicka klinika, Nemocnica Staré Mesto Mickiewiczova 13
813 69 Bratislava, Slovakia
Tel: 224961111
E-mail: [email protected]

Received date: September 09, 2016; Accepted date: October 09, 2016; Published date: October 16, 2016

Citation: Feketova S (2016) Pain in Multiple Sclerosis: Prevalence and Characteristics of Various Pain Conditions. J Mult Scler (Foster City) 3:187. doi:10.4172/2376-0389.1000187

Copyright: © 2016 Feketova S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Pain is a key symptom in patients with multiple sclerosis (MS), but the prevalence of pain in MS and its impact on quality of life of the patients is still underestimated.

Objective: The aim of the study was to examine the occurrence of pain in MS patients, to identify the pain conditions and the relationship to important demographic variables (age, gender, type of MS) and to determine its impact on quality of life.

Methods: Questionnaires on pain and health-related quality of life were sent to 307 patients with definitive MS diagnose. All patients with painful sensations were examined with aim to diagnose central and peripheral neuropathic and nociceptive pain.

Results: Out of 220 responders 92% reported at least one type of pain or unpleasant pain sensation. Pain was more frequent in relapsing-remitting form of MS than in secondary progressive MS (p<0.0001) and less frequent in males than females (p=0,001). The ratio of different pain types was as follows: 51.38% headache, 57.94% neck or low back pain, 40.91% central neuropathic extremity and trunk pain, 5.91% trigeminal neuralgia, 34.26% Lhermitte‘s sign, 2.47% peripheral neuropathic pain. The commonest location of pain was lower extremities (84.09%) and the commonest pain quality was painful stiffness. Two and more concurrent pain locations were reported by 87.2% of patients and the total number of pain locations significantly increases with disease duration (p<0.0001). Pain limited the activities of daily living in 61.5% of patients.

Conclusion: Our study confirmed the heterogenity of pain experienced in MS, the capacity to experience more than one type of pain simultaneously and inadequate pain treatment. Therefore pain is an important therapeutic target in MS.


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