Painful Diabetic Peripheral Neuropathy: Presentations, Mechanisms, and Exercise TherapyMin Yoo1, Neena Sharma1, Mamatha Pasnoor2 and Patricia M Kluding1*
- *Corresponding Author:
- Patricia M Kluding
Department of Physical Therapy and Rehabilitation Science
University of Kansas Medical Center
3901 Rainbow Blvd, MS 3051
Kansas City KS, USA
Tel: (913) 588-6918
Fax: (913) 588-9428
E-mail: [email protected]
Received date May 13, 2013; Accepted date June 24, 2013; Published date June 30, 2013
Citation: Yoo M, Sharma N, Pasnoor M, Kluding PM (2013) Painful Diabetic Peripheral Neuropathy: Presentations, Mechanisms, and Exercise Therapy. J Diabetes Metab S10:005. doi:10.4172/2155-6156.S10-005
Copyright: © 2013 Yoo M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes and a major cause of morbidity and increased mortality. It is typically characterized by significant deficits in tactile sensitivity, vibration sense, lower-limb proprioception, and kinesthesia. Painful diabetic neuropathy (P-DPN) is a common phenotype of DPN that affects up to one-third of the general diabetic population. P-DPN has been shown to be associated with significant reductions in overall quality of life, increased levels of anxiety and depression, sleep impairment, and greater gait variability. The purpose of this review is to examine proposed mechanisms of P-DPN, summarize current treatment regimen, and assess exercise as a potential therapy for P-PDN.
Although exercise has been shown to be an effective therapeutic modality for diabetes, its specific effects on DPN and especially the painful phenotype have not been sufficiently investigated in current literature. Several rodent models and clinical trials have presented promising results in this area, and warrant further investigations examining the effect of exercise on P-DPN.