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Palmitoleic Acid Infusion Alters Circulating Glucose and Insulin Levels | OMICS International | Abstract
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Palmitoleic Acid Infusion Alters Circulating Glucose and Insulin Levels

Long NM, Burns TA, Volpi Lagreca G, Alende M and Duckett SK*
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
Corresponding Author : Susan K Duckett
Department of Animal and Veterinary Science
146 Poole Agricultural Center
Box 340311, Clemson, SC 29634-0311, USA
Tel: 864-656-5151
Fax: 864-656-3131
E-mail: [email protected]
Received May 02, 2014; Accepted June 23, 2014; Published June 26, 2014
Citation: Long NM, Burns TA, Volpi Lagreca G, Alende M, Duckett SK (2014) Palmitoleic Acid Infusion Alters Circulating Glucose and Insulin Levels. J Metabolic Synd 3:148. doi:10.4172/2167-0943.1000148
Copyright: © 2014 Long NM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: The objectives of these studies are to evaluate: 1) uptake of a pulse dose of 13C16:1 cis-9 at varying levels into the blood and 2) glucose and insulin changes after pulse dose of 0 or 5 mg C16:1 cis-9/kg body weight (BW) under challenge conditions in obese lambs.

Methods: Two experiments were conducted to evaluate uptake of U-13C16:1 cis-9 into the blood and changes in glucose and insulin under challenges. In the first experiment, lambs (67.4 ± 1.4 kg BW, n=3) received jugular catheters and were used in a 3 x 3 Latin square. Treatments were 0, 2 or 5 mg/kg BW of U-13C16:1 cis-9 in 40% (wt/v) ethanol and blood samples were collected post infusion for glucose, fatty acid and insulin analyses. In the second experiment, lambs (86.7 ± 1.5 kg BW; n=4) received jugular catheters. Treatments were 0 or 5 mg/kg BW of C16:1 in 40% (wt/v) ethanol immediately followed by a glucose (0.25 g/kg) or insulin (0.02 mIU/kg) challenge.

Results: Both the 2 and 5 mg/kg BW dose of U-13C16:1 cis-9increased (P=0.003) C16:1 cis-9in serum compared to 0 mg/kg BW. The 5 mg/kg BW dose had a greater magnitude of increase for serum C16:1 and resulted in increased whole blood glucose levels for first 60 min and altered insulin levels for first 30 min. During the glucose tolerance test, C16:1bolus infusion increased (P=0.02) peak, overall, and area under the curve for plasma glucose levels. During the insulin challenge, C16:1-treated lambs had increased glucose levels (P=0.04) and peak, overall, and area under the curve plasma insulin (P=0.0001).

Conclusion: Palmitoleic acid infusion results in immediate uptake and clearance of serum palmitoleic acid, increases plasma glucose levels, and alters circulating insulin levels.

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