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Panhypopituitarism, a Cause of Early Sudden Infant Death Syndrome? | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Panhypopituitarism, a Cause of Early Sudden Infant Death Syndrome?

Francesca Viaroli1, Francesca Ormitti2, Susanna Rizzi1 and Cinzia Magnani1*
1Neonatal Intensive Care Unit, Pediatric Department, Parma University Hospital, Italy
2Neuroradiology Unit, Parma University Hospital, Italy
Corresponding Author : Cinzia Magnani
Neonatal Intensive Care Unit
Pediatric Department
Parma University Hospital, Italy
Tel: +390521703518
Fax: +390521702754
E-mail: [email protected]
Received May 15, 2012; Accepted August 25, 2012; Published August 27, 2012
Citation: Viaroli F, Ormitti F, Rizzi S, Magnani C (2012) Panhypopituitarism, a Cause of Early Sudden Infant Death Syndrome? J Clin Case Rep 2:193. doi:10.4172/2165-7920.1000193
Copyright: © 2012 Viaroli F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Panhypopituitarism can manifest itself with variable signs and symptoms, and in some cases it may be responsible for serious events such as cardio-respiratory insufficiency and hypoglycemia which can be fatal. It can be assumed that a condition of panhypopituitarism can cause early sudden death that occurs in the first hours of life. For this reason it is important that the post mortem examination in SIDS (Sudden Infant Death Syndrome) patients includes the study of the pituitary gland. We present a newborn with panhypopituitarism, in which the onset was dramatic, with severe cardio-respiratory insufficiency and severe hypoglycemia and only the accidentally detection by midwives was life saving. Array CGH analysis showed a microdeletion of chromosome 5q34, including part of the intronic region of the gene ODZ2 inherited from the mother, not related to the patient’s symptoms so far.


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