alexa PARADIGM-HF Trial and its Important Clinical Meanings
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
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Commentary

PARADIGM-HF Trial and its Important Clinical Meanings

Jin-lai Liu*
Department of cardiology, The Third Affiliated Hospital, SUN Yat-sun University, Guangzhou 510630, China
Corresponding Author : Jin-lai Liu
Department of cardiology
The Third Affiliated Hospital
SUN Yat-sun University
Guangzhou 510630, China
E-mail: [email protected]
Received: May 26, 2015; Accepted: June 23, 2015; Published: June 25, 2015
Citation: Liu JL (2015) PARADIGM-HF Trial and its Important Clinical Meanings. J Cardiovasc Dis Diagn 3: 205. doi: 10.4172/2329-9517.1000205
Copyright: © 2015 Liu JL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

ACEi/ARB and ß blocker and aldosterone antagonist have been a gold standard for treating chronic heart failure with reduced ejection fraction (HFrEF). The paper described simply the PARADIGM-HF study (Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in HF trial), and the results showed that compared to enalapril, LCZ69(ARNi) significantly reduced the primary endpoint (cardiovascular death or hospitalization for HF) [HR0.80 (95% CI 0.73-0.87)?P<0.001; NNT 21], cardiovascular death [HR0.80 (95% CI 0.71-0.89)?P<0.001; NNT 31], hospitalization for HF [HR0.79 (95% CI 0.71-0.89)?P<0.001; NNT 36], and death from any cause [HR0.84 (95% CI 0.76-0.93), P<0.001; NNT 36]. LCZ696 was well tolerated. The PARADIGM-HF study has an important clinical significance and would change the pattern of HF treatment in the future.

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