alexa Partial Least Squares and Continuous Wavelet Transformation in Simultaneous Spectrophotometric Determination of Amlodipin and Atorvastatine
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Partial Least Squares and Continuous Wavelet Transformation in Simultaneous Spectrophotometric Determination of Amlodipin and Atorvastatine

Masoud Shariati-Rad1*, Mohsen Irandoust1, Tayyebeh Amini1 and Farhad Ahmadi2

1Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran

2Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

*Corresponding Author:
M. Shariati-Rad
Department of Analytical Chemistry, Faculty of Chemistry
Razi University, Kermanshah, Iran
Tel: +98 831 4274559
Fax: +98 831 4274559
E-mail: [email protected]

Received date: October 15, 2012; Accepted date: October 27, 2012; Published date: October 30, 2012

Citation: Shariati-Rad M, Irandoust M, Amini T, Ahmadi F (2012) Partial Least Squares and Continuous Wavelet Transformation in Simultaneous Spectrophotometric Determination of Amlodipin and Atorvastatine. Pharmaceut Anal Acta 3:178. doi: 10.4172/2153-2435.1000178

Copyright: © 2012 Shariati-Rad M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A simple spectrophotometric method for simultaneous determination of amlodipin and atorvastatine in pharmaceutical preparation is proposed based on the partial least squares and continuous wavelet transformation. The resulted partial least squares models were employed for prediction of the two drugs in two brands of combined pharmaceutical preparations which resulted in percent recoveries of 100.7 and 101.4 for amlodipin and 98.6 and 100.1 for atorvastatine. In the best conditions, the results of percent recoveries by continuous wavelet transformation zero-crossing were: 110.3 and 109.0 for amlodipin and 99.7 and 99.7 for atorvastatine for brand 1 and 2, respectively.

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