alexa PASD1: A Promising Target for the Immunotherapy of Haematological Malignancies
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
Open Access

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Review Article

PASD1: A Promising Target for the Immunotherapy of Haematological Malignancies

Ghazala Khan1, Frances Denniss2, Ken I Mills3, Karen Pulford4 and Barbara-ann Guinn1,2*

1Department of Life Sciences, University of Bedfordshire, Park Square, Luton, LU1 3JU, UK

2Department of Haematological Medicine, The Rayne Institute, King’s College London School of Medicine SE5 9NU, UK

3Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, BT9 7BL, UK

4Nuffield Division of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK

*Corresponding Author:
Barbara-ann Guinn
Department of Life Sciences
University of Bedfordshire
Park Square, Luton, LU1 3JU, UK
Tel: +441582743573
E-mail: [email protected]

Received date: August 08, 2013; Accepted date:September 30, 2013; Published date: October 10, 2013

Citation: Khan G, Denniss F, Mills KI, Pulford K, Guinn B (2013) PASD1: A Promising Target for the Immunotherapy of Haematological Malignancies. J Genet Syndr Gene Ther 4:186. doi:10.4172/2157-7412.1000186

Copyright: © 2013 Khan G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In general, there is a lack of good immunotherapy targets within the spectrum of haematological malignancies. However haematopoietic stem cell transplants and continuing antigen discovery have allowed further insight into how further improvements in outcomes for patients might be achieved. Most patients with haematological malignancies can be treated with conventional therapies such as radio- and chemotherapy and will attain first remission. However the removal of residual diseased cells is essential to prevent relapse and its associated high mortality. PASD1 is one of the most tissue restricted cancer-testis (CT) antigens with expression limited to primary spermatagonia in healthy tissue. However, characterisation of PASD1 expression in cancers has been predominantly focussed on haematological malignancies where the inappropriate expression of PASD1 was first identified. PASD1 has one of the highest frequencies of expression of all CT antigens in acute myeloid leukaemia, with some suggestion of its role as a biomarker in diffuse large B-cell lymphoma. Here we describe the characterisation of the function and expression patterns of PASD1 in cell lines and primary tissues. Development of DNA vaccines targeting PASD1 epitopes demonstrate effective ex vivo T-cell responses in terms of IFNγ secretion and tumour cell killing. Of particular note these vaccines have led to the destruction of cells which process and present endogenous PASD1 indicating that effectively primed CTLs could kill PASD1-positive tumour cells.

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