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ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Review Article

Past, Present and Future of Insulin Gene and Its Related Genes In Relation To Polycystic Ovary Syndrome

Amar Nagesh Kumar1*, Jupalle Nagiah Naidu2, Uppala Stayanarayana3 and Medabalmi Anitha4

1Research Scholar, Department of Biochemistry, Narayana Medical College, Dr NTRUHS, Nellore, Andhra Pradesh, India

2Professor and Head, Department of Biochemistry, Narayana Medical College, Nellore, Andhra Pradesh, India

3Research Director and Professor, Department of Biochemistry, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences, Chinnavutapalli, Gannavarm, Andhra Pradesh, India

4Professor and Head, Department of Obstetrics and Gynecology, Narayana Medical College, Nellore, Andhra Pradesh, India

Corresponding Author:
Amar Nagesh Kumar
Research Scholar, Department of Biochemistry
Narayana Medical College, Dr NTRUHS, Andhra Pradesh, India
Tel: +91-9493593750
E-mail: [email protected]

Received date: February 28, 2014; Accepted date: April 10, 2014; Published date: May 10, 2014

Citation: Kumar AN, Naidu JN, Stayanarayanac U, Anitha M (2014) Past, Present and Future of Insulin Gene and Its Related Genes In Relation To Polycystic Ovary Syndrome. J Mol Genet Med 8:107. doi: 10.4172/1747-0862.1000107

Copyright: © 2014 Kumar AN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Abstract

Polycystic ovary syndrome is the most common endocrinal disorder and is associated with infertility. Insulin resistance is a key component in the pathogenesis of PCOS and the predisposition to Type 2 diabetes mellitus. The existing literature supports a strong basis of PCOS clusters in families. However, due to the genetic and phenotypic heterogeneity of PCOS and the lack of large cohort studies and identification of specific contributing genes to date have yielded only few conclusive results. Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, and a region near the insulin receptor, the strongest case can be made for the region near the insulin receptor gene. Insulin receptor substrates proteins (IRS) are critical for insulin mediated signal transduction in insulin target tissues. Several studies have shown that IRS-1 Gly972Arg polymorphism might be the factor causing susceptibility to Type 2 diabetes mellitus (T2DM) and are associated with phenotypic features of
PCOS. In this article we reviewed the current status of the genetic analysis of insulin (INS), insulin  receptor (INSR), insulin receptor substrate (IRS) in relation to polycystic ovary syndrome, an infertility disorder in females.

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