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ISSN: 2329-9495

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Research Article

Pathogenic Mechanism of the Artery and the Vein in Buerger Disease: Our Hypothesis

Takehisa Iwai11*, Makoto Umeda2, Yoshinori Inoue3 and Tokyo Medical and Dental University Buerger Disease Research Group

1Tsukuba Vascular Center, NPO Buerger Disease Research Institute, Japan

2Department Periodontology, Osaka Dental University, Japan

3Vascular Surgery Service, Tokyo Medical and Dental University, Japan

*Corresponding Author:
Takehisa Iwai
Tsukuba Vascular Center
NPO Buerger Disease Research Institute
980-1, Tatsuzawa, Moriya city
Ibaraki prefecture, 302-4541, Japan
Tel: +81297479955
Fax: +81298454541
E-mail: [email protected]

Received Date: May 16, 2014; Accepted Date: July 21, 2014; Published Date: August 04, 2014

Citation: Iwai T, Umeda M, Inoue Y et al. (2014) Pathogenic Mechanism of the Artery and the Vein in Buerger Disease: Our Hypothesis. Angiol 2:131. doi:10.4172/2329-9495.1000131

Copyright: © 2014 Iwai T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Our hypothesis started from the discovery of the periodontal bacteria DNA in occluded arteries and phlebitis veins of Buerger disease. It was accelerated by the observation of platelets and bacterial coexistence showing aggregation of platelets. Using our hypothesis, we would like to explain the characteristic points of Buerger disease that have already been reported in various documents. Our hypothesis of Buerger disease is able to explain the signs and symptoms pretty easily. More investigations are necessary to understand the full story of the disease. The infection of the thrombus is the core of the disease. Angiitis is a secondary reaction of the intimal area.

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