alexa Pathology Features and Molecular Genetic Mechanisms of Hepatocellular Carcinoma Development in Patients with Hepatitis C Associated Liver Cirrhosis | OMICS International
ISSN: 2161-1041

Hereditary Genetics: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Editorial

Pathology Features and Molecular Genetic Mechanisms of Hepatocellular Carcinoma Development in Patients with Hepatitis C Associated Liver Cirrhosis

Lijiang Ma*

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center New York, USA

*Corresponding Author:
Lijiang Ma
Division of Molecular Genetics, Department of Pediatrics
Columbia University Medical Center New York, NY 10032, USA
Tel: 212-851-5318
Fax: 212-851-5306
E-mail: [email protected]

Received date May 23, 2014; Accepted date: May 24, 2014; Published date: May 26, 2014

Citation: Ma L (2014) Pathology Features and Molecular Genetic Mechanisms of Hepatocellular Carcinoma Development in Patients with Hepatitis C Associated Liver Cirrhosis. Hereditary Genet 3:e109. doi: 10.4172/2161-1041.1000e109

Copyright: © 2014 Ma L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hepatitis C virus (HCV) is a single stranded RNA virus belonging to the family of Flaviviridae. The hepatitis C virus has unique ability to cause persistent infection in susceptible host. The chronicity rate is 75-85% after acute infection and 20-30% of HCV infected patients will develop cirrhosis, end-stage liver disease or hepatocellular carcinoma (HCC). Post transfusion HCV has been virtually eliminated by screening of donor blood after 1992 and injection drug use now appears to be the most common remaining risk factor for HCV infection. Chronic infection of HCV is a major risk of hepatocellular carcinoma and the pathogenesis of HCC in chronic HCV infection is due to chronic inflammation for long period of time which leads to fibrosis, cirrhosis and carcinoma formation. Pathology features of chronic hepatitis C, cirrhosis and hepatocellular carcinoma were described. Molecular genetic mechanisms involved in the development of hepatitis C associated cirrhosis and hepatocellular carcinoma were reviewed. Understanding the mechanisms of initiation and progression of HCC will provide principles for early diagnosis, treatment, and prevention.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version