Pathophysiologic Changes after Brain Death and Organ Preservation: the Intensivist Ã¢ÂÂ s and Anesthesiologist Ã¢ÂÂ s Role
- *Corresponding Author:
- Rudin Domi
Department Of Anesthesiology and Intensive Care
“Mother Teresa” University Hospital Center
Tirana, Albania, USA
E-mail: [email protected]
Received date: February 28, 2013; Accepted date: March 27, 2013; Published date: March 29, 2013
Citation: Domi R, Sula H, Ohri I, Laho H (2013) Pathophysiologic Changes after Brain Death and Organ Preservation: the Intensivist’s and Anesthesiologist’s Role. J Anesthe Clinic Res 4:302. doi: 10.4172/2155-6148.1000302
Copyright: © 2013 Domi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organ transplantation is considered as a definitive surgical therapy for the end-stage organ failure patients, in order to improve the life quality and patients ‘survival. Organ donation may be considered only after the death or brain death is medically and legally confirmed, unless a living donation is being considered. The physician must know the pathophysiology of brain death, in order to ensure organ function is preserved. The physician must deal with brisk hemodynamic changes, endocrine and metabolic abnormalities, and respiratory complications. General measures are maintaining blood pressure and tissue oxygenation, fluid therapy to correct volume status, hormonal supplements, normoglycemia, respiratory care, and major organ function preservation.