alexa PCR-SBT Characterization of A New HLA Allele: A*02:548
ISSN: 2471-9552

Immunotherapy: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Commentary

PCR-SBT Characterization of A New HLA Allele: A*02:548

Valentina Cappuzzo*, Francesco Ingrassia, Rosalba Bavetta, Serena Mistretta, Maria Blando, Igea Vega, Emanuela Collura and Raimondo Marcenò

Laboratory of Tipizzazione Tessutale ed Immunogenetica, Medicina Trasfusionale – A.O, Ospedali Riuniti Villa Sofia-Cervello, via Trabucco, 180- 90146 Palermo, Italy

*Corresponding Author:
Valentina Cappuzzo
Laboratory of Tipizzazione Tessutale ed
Immunogenetica, Medicina Trasfusionale – A.O
Ospedali Riuniti Villa Sofia-
Cervello, via Trabucco
180- 90146 Palermo, Italy
Tel: 390916802980
E-mail: [email protected]

Received date: January 18, 2016; Accepted date: February 9, 2016; Published date: February 18, 2016

Citation: Cappuzzo V, Ingrassia F, Bavetta R, Mistretta S, Marceno R, et al. (2016) PCR-SBT Characterization of A New HLA Allele: A*02:548. Immunother Open Acc 2:112. doi:10.4172/2471-9552.1000112

Copyright: © 2016 Cappuzzo V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The human Major Histocompatibility Complex (MHC) lies within the short arm of chromosome 6 and is responsible for the production of Human Leukocyte Antigens (HLA). The HLA genes are the most polymorphic genes in the human genome, encoding over 13000 allelic variants. Our laboratories are involved in HLA tissue typing of patients, their relatives and volunteer donors for the Italian Bone Marrow Register. During HLA-A high resolution typing of our Caucasian bone marrow volunteer donors, we found a sequence largely homologous to A*02:01 with a mutation at position 367 a C instead of a T. This mutation results in a coding change from Tyrosine to Histidine in exon 3 (codon 99 TAT→CAT). This allele was then submitted to the WHO Nomenclature Committee via the IMGT/HLA Database for naming and was assigned the official name A*02:548.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords