alexa Donepezil for Constipation in Lewy Body Disease: A Twelve-Month Follow-Up | OMICS International| Abstract
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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  • Short Communication   
  • J Mol Genet Med 2018, Vol 12(1): 337
  • DOI: 10.4172/1747-0862.1000337

Donepezil for Constipation in Lewy Body Disease: A Twelve-Month Follow-Up

Lepkowsky CM*
, Independent Practice, 1143 Deer TrailLane, Solvang, California, USA
*Corresponding Author : Lepkowsky CM, Independent Practice, 1143 Deer TrailLane, Solvang, California-93463, USA, Tel: 805 688-1229, Fax: 805 686-9382, Email: [email protected]

Received Date: Mar 08, 2018 / Accepted Date: Mar 14, 2018 / Published Date: Mar 19, 2018


Previously, the acetylcholinesterase inhibitor Donepezil was used in a case study to address the symptoms of constipation, obstipation, and impaction in four patients with Lewy Body diseases. In patients with both Parkinson’s disease (PD) and Neurocognitive Disorder with Lewy Bodies (NCDLB), the use of Donepezil led to symptom reduction. After six months, the symptoms of the same patients were reviewed, with no loss of bowel motility nor emergence of new symptoms. After twelve months, another review of symptoms was conducted. The results indicate that Donepezil appears to be effective in reducing the symptoms of constipation, obstipation and impaction over an extended period of treatment.

Keywords: Neurocognitive disorder with lewy bodies; Parkinson's disease; Constipation; Donepezil; Acetylcholinesterase inhibitor

Citation: Lepkowsky CM (2018) Donepezil for Constipation in Lewy Body Disease: A Twelve-Month Follow-Up. J Mol Genet Med 12: 337. Doi: 10.4172/1747-0862.1000337

Copyright: © 2018 Lepkowsky CM.This is an open-access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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