alexa Peculiar Characteristics of Human Mesenchymal Stem Cell Clones Suitable as Tissue Engineering Models
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Research Article

Peculiar Characteristics of Human Mesenchymal Stem Cell Clones Suitable as Tissue Engineering Models

Giulia Silvani1,2*, Daniela Galli1,2, Laura Benedetti1,2, Gabriele Ceccarelli1,2, Nicola Crosetto4, Carla Olivieri3, Cesare Danesino3 and Maria Gabriella Cusella De Angelis1,2

1Dipartimento di Medicina Sperimentale, University of Pavia , Italy

2Centro di Ingegneria Tissutale, University of Pavia, Italy

3Department of Hereditary and Human Pathology, University of Pavia, Italy

4The van Oudenaarden Systems Biology Lab, Massachusetts Institute of Technology 77 Mass. Av. 68-383 Cambridge, MA 02139, USA

Corresponding Author:
Dr. Giulia Silvani
Dipartimento di Medicina Sperimentale
University of Pavia, Italy
Tel:+39-0382987661
Fax: +39-0382422117
Email: [email protected]

Received date: May 31, 2011; Accepted date: July 07, 2011; Published date: July 09, 2011

Citation: Silvani G, Galli D, Benedetti L, Ceccarelli G, Crosetto N, et al. (2011) Peculiar Characteristics of Human Mesenchymal Stem Cell Clones Suitable as Tissue Engineering Models. J Tissue Sci Eng 2:106. doi:10.4172/2157-7552.1000106

Copyright: © 2011 Silvani G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In the last few years? stem cell research contributed to gain a fundamental understanding of how organisms grow and develop and how tissues are maintained throughout adult life. Mesenchymal stem cells (MSC) are self renewing, multipotent cells that are present in many adult tissues, such as bone marrow, adipose tissue, trabecular bone and muscle. More recently they have been found also in skin, liver and other tissues. Dermal skin-derived fibroblasts exhibit mesenchymal surface antigen immunophenotype and differentiation capabilities versus the three main mesenchymal tissues (bone, fat and cartilage). Hereditary Hemorrhagic Telangiectasia affects 1 in 5000 people and leads to abnormal blood vessel formation in skin and mucous membranes. We isolated human dermal fibroblasts from patients with Hereditary Hemorrhagic Telangiectasia (HHT) and healthy controls. In order to evaluate future applications of these cells in tissue engineering we compared mesenchymal properties (self-renewal, differentiation potential) of human gingival fibroblasts isolated from healthy and HHT-affected subjects using a combination of phenotypic (flow cytometry), morphologic (senescence), and functional (in vitro differentiation, colony forming unit assay and proliferation assay) criteria. Our results suggest that HHT cells were ideal candidates for tissue engineering.

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