alexa Penicillin: The Old/New Wonder Drug
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
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Review Article

Penicillin: The Old/New Wonder Drug

Herbert B Allen*, Claudia Hossain, Nadia Abidi, Mary Larijani and Suresh G Joshi

Department of Dermatology, Drexel University College of Medicine, Philadelphia, USA

Corresponding Author:
Herbert B Allen, MD
219 N. Broad St.
4th floor Philadelphia PA 19107, USA
Tel: 2157525550
Fax: 2157625570
E-mail: [email protected]

Received date: December 20, 2016; Accepted date: January 03, 2017; Published date: January 10, 2017

Citation: Allen HB, Hossain C, Abidi N, Larijani M, Joshi SG (2017) Penicillin: The Old/New Wonder Drug. Adv Tech Biol Med 5:197. doi:10.4172/2379- 1764.1000197

Copyright: © 2017 Allen HB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Penicillin (PCN) has been shown to treat psoriasis effectively and be curative in many cases. Streptococcus is the organism responsible for beginning the process and has previously escaped detection by moving intracellularly or by forming biofilms. The treatment is low dose for many months and thus is similar to rheumatic fever. Arthritis has been shown to be caused by biofilm-forming dental and Lyme spirochetes, and these organisms, like the streptococcus in psoriasis, have escaped detection. Penicillin, plus a biofilm-dispersing agent is effective in treating arthritis in which tissue destruction has not already occurred. Alzheimer’s disease has been shown to be caused by those same spirochetes involved in arthritis, and, is in every way, similar to the dementia of neurosyphilis caused by Treponema pallidum. These organisms make biofilms that induce B amyloid and a Toll-like receptor 2 response leading to tissue destruction. Penicillin given prior to the organisms arrival in the brain (or before they create biofilms) would effectively prevent dementia in Alzheimer’s as it does in syphilis. We have shown that biofilm-forming staphylococci are integral to the etiology of atopic dermatitis. Along with standard corticosteroid therapy, antibacterial treatment, as opposed to antibiotics, appears to be a better treatment in AD because all the organisms are multi-drug resistant and 60% are MRSA or MSRE. Treatment with PCN in psoriasis, arthritis, and syphilis, has thus far not led to resistance and may actually prevent resistance by killing organisms before they make biofilms and share resistance genes.


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