alexa Pentacyclic Triterpenes from the Ethyl Acetate Fraction
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

Pentacyclic Triterpenes from the Ethyl Acetate Fraction of the Bark of Platanus acerifolia Wild and Antitumor Activities In Vitro

Chuan-Jin Wang* and Wei Li
Department of Pharmaceutical Engineering, Institute of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
*Corresponding Author : Chuan-Jin Wang
Department of Pharmaceutical Engineering
Institute of Chemical Engineering
Nanjing University of Science and Technology
Nanjing, 210094, China
Tel: +862584315514
E-mail: [email protected]
Received: February 11, 2016; Accepted: March 27, 2016; Published: March 31, 2016
Citation: Wang CJ, Li W (2016) Pentacyclic Triterpenes from the Ethyl Acetate Fraction of the Bark of Platanus acerifolia Wild and Antitumor Activities In Vitro. Mod Chem appl 4:178. doi:10.4172/2329-6798.1000178
Copyright: © 2016 Wang CJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Three pentacyclic triterpenes, named betulinic acid (1), 11α-hydroxy-β-amyrin (2) 3β-acetoxy-20 (29)-lupen- 28-aldehyde (3) were isolated from the ethyl acetate fraction of the bark of Platanus acerifolia Willd. The molecular structure of 1 and were established on the basis of various spectroscopic analyses. The molecular structure of (3) was determined by single-crystal X-ray diffraction. Compound (2) and (3) were obtained from the title plant for the first time. Cytotoxicity of the isolated compounds against three human cancer cell lines, HepG-2, MCF-7 and HL-60 were also determined with the cell counting kit-8 (CCK-8) assay. The target compounds showed the high cytotoxicity, with IC50 values in the range 2.2-9.1 μM. These results indicated that pentacyclic triterpenes from the bark of Platanus acerifolia Willd could be explored as potential cancer prevention agents.

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